Microstructural MRI Basis of the Cognitive Functions in Patients with Spinocerebellar Ataxia Type 2

被引：27

作者：

Olivito, G. ^{[1
,2
]}

Lupo, M. ^{[1
]}

Iacobacci, C. ^{[1
,3
]}

Clausi, S. ^{[1
,4
]}

Romano, S. ^{[5
]}

Masciullo, M. ^{[6
]}

Molinari, M. ^{[7
]}

Cercignani, M. ^{[2
,8
]}

Bozzali, M. ^{[2
,8
]}

Leggio, M. ^{[1
,4
]}

机构：

[1] IRCCS Santa Lucia Fdn, Ataxia Lab, Via Ardeatina 306, I-00179 Rome, Italy

[2] IRCCS Santa Lucia Fdn, Neuroimaging Lab, Via Ardeatina 306, I-00179 Rome, Italy

[3] Sapienza Univ Rome, PhD Program Behav Neurosci, Rome, Italy

[4] Sapienza Univ Rome, Dept Psychol, Rome, Italy

[5] Sapienza Univ Rome, St Andrea Hosp, Dept Neurosci Mental Hlth & Sensory Organs NESMOS, Rome, Italy

[6] IRCCS Fdn Santa Lucia, SPInalREhabil Lab, Rome, Italy

[7] IRCCS Fdn Santa Lucia, Robot Neurorehabil Lab, Neurorehabil & Spinal Ctr 1, Rome, Italy

[8] Brighton & Sussex Med Sch, Clin Imaging Sci Ctr, Brighton, E Sussex, England

来源：

NEUROSCIENCE | 2017年 / 366卷

关键词：

DTI; tractography; cerebellum; cerebellar peduncles; white matter; cognition; CROSSED CEREBELLOCEREBRAL DIASCHISIS; VOXEL-BASED MORPHOMETRY; CENTRAL HYPOVENTILATION SYNDROME; AMYOTROPHIC-LATERAL-SCLEROSIS; SPATIAL STATISTICS; CEREBELLAR PEDUNCLES; MULTIPLE-SCLEROSIS; NORMATIVE VALUES; WATER DIFFUSION; AXONAL INJURY;

D O I：

10.1016/j.neuroscience.2017.10.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disease involving the cerebellum. The particular atrophy pattern results in some typical clinical features mainly including motor deficits. In addition, the presence of cognitive impairments, involving language, visuospatial and executive functions, has been also shown in SCA2 patients and it is now widely accepted as a feature of the disease. The aim of the study is to investigate the microstructural patterns and the anatomo-functional substrate that could account for the cognitive symptomatology observed in SCA2 patients. In the present study, diffusion tensor imaging (DTI) based-tractography was performed to map the main cerebellar white matter (WM) bundles, such as Middle and Superior Cerebellar Peduncles, connecting cerebellum with higher order cerebral regions. Damage-related diffusivity measures were used to determine the pattern of pathological changes of cerebellar WM microstructure inpatients affected by SCA2 and correlated with the patients' cognitive scores. Our results provide the first evidence that WM diffusivity is altered in the presence of the cerebellar cortical degeneration associated with SCA2 thus resulting in a cerebello-cerebral dysregulation that may account for the specificity of cognitive symptomatology observed in patients. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：44 / 53

页数：10

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