Toxic effects of ionic magnetic fluids in mice

被引：53
作者：
Lacava, ZGM [1 ]
Azevedo, RB
Lacava, LM
Martins, EV
Garcia, VAP
Rébula, CA
Lemos, APC
Sousa, MH
Tourinho, FA
Morais, PC
Da Silva, MF
机构：
[1] Univ Brasilia, Dept Genet & Morfol, Inst Biol, BR-70910900 Brasilia, DF, Brazil
[2] Univ Brasilia, Dept Quim, BR-70910900 Brasilia, DF, Brazil
[3] Univ Brasilia, Inst Fis, BR-70910900 Brasilia, DF, Brazil
来源：
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 1999年 / 194卷 / 1-3期
关键词：
ferrofluid; ionic magnetic fluid; tartrate-based magnetic fluid; toxicity; macrophage; biocompatible material;
D O I：
10.1016/S0304-8853(98)00583-6
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Toxicity of ionic and tartrate-based magnetic fluids administered intraperitoneally to mice was investigated through morphological and cytometric alterations and cytogenetic analysis. Both magnetic fluids cause cellular death, mutagenicity and severe inflammatory reactions, being very toxic and thus not biocompatible. Peritoneal cell and tissue studies may provide a useful strategy to investigate the in vivo biological effects of magnetic nanoparticles. (C) 1999 Elsevier Science B.V. All rights reserved.
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页码：90 / 95
页数：6
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