First case of SARS-COV-2 sequencing in cerebrospinal fluid of a patient with suspected demyelinating disease

被引：102

作者：

Domingues, Renan Barros ^{[1
]}

Mendes-Correa, Maria Cassia ^{[2
]}

de Moura Leite, Fernando Brunale Vilela ^{[1
]}

Sabino, Ester Cerdeira ^{[3
]}

Salarini, Diego Zanotti ^{[4
]}

Claro, Ingra ^{[3
]}

Santos, Daniel Wagner ^{[4
]}

de Jesus, Jaqueline Goes ^{[3
]}

Ferreira, Noely Evangelista ^{[3
]}

Romano, Camila Malta ^{[3
]}

Soares, Carlos Augusto Senne ^{[1
]}

机构：

[1] Senne Liquor Diagnost, Sao Paulo, SP, Brazil

[2] Univ Sao Paulo, Inst Med Trop, Virol Sect LIM 52, Sao Paulo, SP, Brazil

[3] Inst Med Trop Sao Paulo, Sao Paulo, SP, Brazil

[4] Hosp Sao Luiz Jabaquara, Rede DOr, Sao Paulo, SP, Brazil

来源：

JOURNAL OF NEUROLOGY | 2020年 / 267卷 / 11期

关键词：

COVID-19; SARS-COV-2; Clinically isolated syndrome; Cerebrospinal fluid; INFECTION; CORONAVIRUSES;

D O I：

10.1007/s00415-020-09996-w

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The association between coronaviruses and central nervous system (CNS) demyelinating lesions has been previously shown. However, no case has been described of an association between the novel coronavirus (SARS-COV-2) and CNS demyelinating disease so far. SARS-COV-2 was previously detected in cerebrospinal fluid (CSF) sample of a patient with encephalitis. However, the virus identity was not confirmed by deep sequencing of SARS-COV-2 detected in the CSF. Here, we report a case of a patient with mild respiratory symptoms and neurological manifestations compatible with clinically isolated syndrome. The viral genome of SARS-COV-2 was detected and sequenced in CSF with 99.74-100% similarity between the patient virus and worldwide sequences. This report suggests a possible association of SARS-COV-2 infection with neurological symptoms of demyelinating disease, even in the absence of relevant upper respiratory tract infection signs.

引用

页码：3154 / 3156

页数：3

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