Monomicrobial Fournier's Gangrene Caused by Panton-Valentine Leukocidin-negative Methicillin-susceptible Staphylococcus aureus ST8 in Japan

被引：2

作者：

Yamagishi, Hirofumi ^{[1
]}

Kawahori, Kenichi ^{[1
]}

Ohkiba, Noriaki ^{[1
]}

Murooka, Nozomi ^{[1
]}

Inazawa, Takeshi ^{[1
]}

机构：

[1] Kashiwa Municipal Hosp, Dept Endocrinol & Metab, Kashiwa, Chiba, Japan

来源：

INTERNAL MEDICINE | 2020年 / 59卷 / 14期

关键词：

Fournier's gangrene; methicillin-susceptible Staphylococcus aureus ST8; Panton-Valentine leukocidin; toxic shock syndrome toxin-1; GENETIC DIVERSITY; USA300; CLONE; RESISTANT; COMMUNITY; INFECTIONS; MRSA; VIRULENCE; SEQUENCE; STRAINS;

D O I：

10.2169/internalmedicine.4334-19

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Methicillin-resistant Staphylococcus aureus USA300, belonging to sequence type (ST) 8, is a rare cause of necrotizing fasciitis in the USA. We herein report a case of monomicrobial Fournier's gangrene caused by an ST8, methicillin-susceptible Staphylococcus aureus (designated kswl). Whole-genome sequencing and analyses for virulence determinants revealed that, unlike USA300, kswl lacked virulence genes, such as Panton-Valentine leukocidin and SCCmec, while harboring the toxic shock syndrome toxin-1 gene. These genomic features correlate with ST8 CA-MRSA/J, which is the major genotype of ST8 in Japan.

引用

页码：1769 / 1772

页数：4

共 25 条

[1] Comparing Whole-Genome Sequencing with Sanger Sequencing for spa Typing of Methicillin-Resistant Staphylococcus aureus [J].

Bartels, Mette Damkjaer ;

Petersen, Andreas ;

Worning, Peder ;

Nielsen, Jesper Boye ;

Larner-Svensson, Hanna ;

Johansen, Helle Krogh ;

Andersen, Leif Percival ;

Jarlov, Jens Otto ;

Boye, Kit ;

Larsen, Anders Rhod ;

Westh, Henrik .

JOURNAL OF CLINICAL MICROBIOLOGY, 2014, 52 (12) :4305-4308

[2] STAPHYLOCOCCUS-AUREUS LEUKOCIDIN - A NEW VIRULENCE FACTOR IN CUTANEOUS INFECTIONS - AN EPIDEMIOLOGIC AND EXPERIMENTAL-STUDY [J].

CRIBIER, B ;

PREVOST, G ;

COUPPIE, P ;

FINCKBARBANCON, V ;

GROSSHANS, E ;

PIEMONT, Y .

DERMATOLOGY, 1992, 185 (03) :175-180

[3] Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus [J].

Diep, BA ;

Gill, SR ;

Chang, RF ;

Phan, TH ;

Chen, JH ;

Davidson, MG ;

Lin, F ;

Lin, J ;

Carleton, HA ;

Mongodin, EF ;

Sensabaugh, GF ;

Perdreau-Remington, F .

LANCET, 2006, 367 (9512) :731-739

[4] Widespread skin and soft-tissue infections due to two methicillin-resistant Staphylococcus aureus strains harboring the genes for Panton-Valentine leucocidin [J].

Diep, BA ;

Sensabaugh, GF ;

Somboona, NS ;

Carleton, HA ;

Perdreau-Remington, F .

JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (05) :2080-2084

[5] Fournier's gangrene: a review of 1726 cases [J].

Eke, N .

BRITISH JOURNAL OF SURGERY, 2000, 87 (06) :718-728

[6] Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus [J].

Enright, MC ;

Day, NPJ ;

Davies, CE ;

Peacock, SJ ;

Spratt, BG .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (03) :1008-1015

[7] Staphylococcus aureus Panton-Valentine leukocidin directly targets mitochondria and induces Bax-independent apoptosis of human neutrophils [J].

Genestier, AL ;

Michallet, MC ;

Prévost, G ;

Bellot, G ;

Chalabreysse, L ;

Peyrol, S ;

Thivolet, F ;

Etienne, J ;

Lina, G ;

Vallette, FM ;

Vandenesch, F ;

Genestier, L .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (11) :3117-3127

[8] Epidural abscess caused by community-associated methicillin-resistant Staphylococcus aureus strain USA300 in Japan [J].

Higashiyama, Masaaki ;

Ito, Teruyo ;

Han, Xiao ;

Ono, Kenichiro ;

Minamimura, Kenzo ;

Sakakibara, Fumihiro ;

Tanno, Akemi ;

Nishiyama, Junichiro ;

Hatada, Junichi ;

Hiramatsu, Keiichi ;

Kawana, Akihiko .

JOURNAL OF INFECTION AND CHEMOTHERAPY, 2010, 16 (05) :345-349

[9] Molecular characteristics of the Taiwanese multiple drug-resistant ST59 clone of Panton-Valentine leucocidin-positive community-acquired methicillin-resistant Staphylococcus aureus from pediatric cellulitis [J].

Higuchi, Wataru ;

Hung, Wei-Chun ;

Takano, Tomomi ;

Iwao, Yasuhisa ;

Ozaki, Kyoko ;

Isobe, Hirokazu ;

Teng, Lee-Jene ;

Shimazaki, Tetsuya ;

Honda, Akihito ;

Higashide, Masato ;

Hanaki, Hideaki ;

Yamamoto, Tatsuo .

JOURNAL OF INFECTION AND CHEMOTHERAPY, 2010, 16 (02) :144-149

[10] The emerging ST8 methicillin-resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomics [J].

Iwao, Yasuhisa ;

Ishii, Rumiko ;

Tomita, Yusuke ;

Shibuya, Yasuhiro ;

Takano, Tomomi ;

Hung, Wei-Chun ;

Higuchi, Wataru ;

Isobe, Hirokazu ;

Nishiyama, Akihito ;

Yano, Mio ;

Matsumoto, Tetsuya ;

Ogata, Kikuyo ;

Okubo, Takeshi ;

Khokhlova, Olga ;

Ho, Pak-Leung ;

Yamamoto, Tatsuo .

JOURNAL OF INFECTION AND CHEMOTHERAPY, 2012, 18 (02) :228-240

← 1 2 3 →