Crystal engineering of multiple-component organic solids: Pharmaceutical cocrystals of tadalafil with persistent hydrogen bonding motifs

被引：35

作者：

Weyna, David R. ^{[1
]}

Cheney, Miranda L. ^{[1
]}

Shan, Ning ^{[1
]}

Hanna, Mazen ^{[1
]}

Wojtas, Lukasz ^{[2
]}

Zaworotko, Michael J. ^{[2
]}

机构：

[1] Thar Pharmaceut Inc, Tampa, FL 33612 USA

[2] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

来源：

CRYSTENGCOMM | 2012年 / 14卷 / 07期

关键词：

SELECTIVE PDE5 INHIBITOR; PHARMACOKINETICS; SOLUBILITY; DISCOVERY;

D O I：

10.1039/c2ce06574f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pharmaceutical cocrystals of tadalafil with methylparaben, propylparaben and hydrocinnamic acid have been prepared and characterized. The crystal packing observed in the three resulting cocrystals reveals that tadalafil molecules form persistent hydrogen-bonded chains which accept additional hydrogen bonds from the OH moieties of the respective coformers.

引用

页码：2377 / 2380

页数：4

共 23 条

[21] Multi-component hydrogen-bonding organic salts formed from 1-methylpiperazine with aromatic carboxylic acids: Synthons cooperation and crystal structures
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Chemical Research in Chinese Universities, 2015, 31 : 9 - 15
[22] A persistent preference for layer motifs in self-assemblies of squarates and hydrogen squarates by hydrogen bonding [X-H center dot center dot center dot O; X=N, O, or C]: A crystallographic study of five organic salts
Karle, IL
Ranganathan, D
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[23] MANIFESTATIONS OF NONCOVALENT BONDING IN THE SOLID-STATE .6. [H-4(CYCLAM)](4+) (CYCLAM=1,4,8,11-TETRAAZACYCLOTETRA-DECANE) AS A TEMPLATE FOR CRYSTAL ENGINEERING OF NETWORK HYDROGEN-BONDED SOLIDS
SUBRAMANIAN, S
ZAWOROTKO, MJ
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1995, 73 (03): : 414 - 424

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