Crystal engineering of multiple-component organic solids: Pharmaceutical cocrystals of tadalafil with persistent hydrogen bonding motifs

被引：35
|
作者：
Weyna, David R. [1 ]
Cheney, Miranda L. [1 ]
Shan, Ning [1 ]
Hanna, Mazen [1 ]
Wojtas, Lukasz [2 ]
Zaworotko, Michael J. [2 ]
机构：
[1] Thar Pharmaceut Inc, Tampa, FL 33612 USA
[2] Univ S Florida, Dept Chem, Tampa, FL 33620 USA
来源：
CRYSTENGCOMM | 2012年 / 14卷 / 07期
关键词：
SELECTIVE PDE5 INHIBITOR; PHARMACOKINETICS; SOLUBILITY; DISCOVERY;
D O I：
10.1039/c2ce06574f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Pharmaceutical cocrystals of tadalafil with methylparaben, propylparaben and hydrocinnamic acid have been prepared and characterized. The crystal packing observed in the three resulting cocrystals reveals that tadalafil molecules form persistent hydrogen-bonded chains which accept additional hydrogen bonds from the OH moieties of the respective coformers.
引用
收藏
页码：2377 / 2380
页数：4
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