Advances in Pulmonary Delivery of Nanoparticles

被引：32

作者：

Kaur, Gunjeet ^{[1
]}

Narang, R. K. ^{[1
]}

Rath, Goutam ^{[1
]}

Goyal, Amit K. ^{[1
]}

机构：

[1] ISF Coll Pharm, Dept Pharmaceut, Nanomed Res Ctr, Moga 142001, Punjab, India

来源：

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY | 2012年 / 40卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

Pulmonary delivery; Lipidic nanoparticles; Polymeric nanoparticles; Metallic inorganic particles; Lungs; SOLID LIPID NANOPARTICLES; IN-VIVO EVALUATION; DRUG-DELIVERY; ALVEOLAR MACROPHAGES; LUNG DEPOSITION; DRY POWDER; HYDROFLUOROALKANE PROPELLANTS; GOLD NANOPARTICLES; TARGETED DELIVERY; SUSTAINED-RELEASE;

D O I：

10.3109/10731199.2011.592494

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nanotechnology has potential in the development of novel and effective delivery of drugs within lungs. Different strategies have been utilized for pulmonary delivery of drugs, including the use of lipid-based delivery systems (liposomes, ISCOMs, SLNs), use of polymeric matrix (PLGA, poly caprolactone, cynoacrylates, gelatin), development of polysaccharide particulates (chitosan, alginates, Carbopol, etc.), biocompatible metallic inorganic particles (iron, gold, zinc), etc. This paper reviews various nanopaticulate approaches in the form of lipids, polymers, metals, polysaccharides, or emulsions based for pulmonary drug delivery that could provide an increased biological efficacy and better local and systemic action.

引用

页码：75 / 96

页数：22

共 117 条

[1]

Ahmad Z, 2008, EXPERT OPIN DRUG DEL, V5, P1323, DOI [10.1517/17425240802600662, 10.1517/17425240802600662 ]

[2] Secondary cytotoxicity mediated by alveolar macrophages: A contribution to the total efficacy of nanoparticles in lung cancer therapy? [J].

Al-Hallak, Kamal M. H. D. ;

Azarmi, Shirzad ;

Anwar-Mohamed, Anwar ;

Roa, Wilson H. ;

Loebenberg, Raimar .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2010, 76 (01) :112-119

[3] Stabilizing protein formulations during air-jet nebulization [J].

Albasarah, Yacoub Y. ;

Somavarapu, Satyanarayana ;

Taylor, Kevin M. G. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 402 (1-2) :140-145

[4] Preparation and characterization of biodegradable paclitaxel loaded alginate microparticles for pulmonary delivery [J].

Alipour, Shohreh ;

Montaseri, Hashem ;

Tafaghodi, Mohsen .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2010, 81 (02) :521-529

[5] FURNACE-GENERATED ACID AEROSOLS - SPECIATION AND PULMONARY EFFECTS [J].

AMDUR, MO ;

CHEN, LC .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1989, 79 :147-150

[6]

Anais JP, 2009, DRUG DEV IND PHARM, V35, P216, DOI [10.1080/03639040802248798, 10.1080/03639040802248798 ]

[7]

ANDERSON MW, 1974, J PHARMACOL EXP THER, V189, P456

[8] NanoCipro encapsulation in monodisperse large porous PLGA microparticles [J].

Arnold, Matthew M. ;

Gonnan, Enic M. ;

Schieber, Loren J. ;

Munson, Eric J. ;

Berkland, Cory .

JOURNAL OF CONTROLLED RELEASE, 2007, 121 (1-2) :100-109

[9]

Arora Daisy, 2010, Current Immunology Reviews, V6, P234

[10] Cationic liposomes as carriers for aerosolized formulations of an anionic drug: Safety and efficacy study [J].

Bai, Shuhua ;

Gupta, Vivek ;

Ahsan, Fakhrul .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 38 (02) :165-171

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