Synthesis of a cell-permeable analogue of a glycosylphosphatidylinositol (GPI) intermediate that is toxic to the living bloodstream form of Trypanosoma brucei

被引：6

作者：

Crossman, A ^{[1
]}

Smith, TK ^{[1
]}

Ferguson, MAJ ^{[1
]}

Brimacombe, JS ^{[1
]}

机构：

[1] Univ Dundee, Sch Life Sci, Wellcome Trust Bioctr, Div Biol Chem & Mol Microbiol, Dundee DD1 5EH, Scotland

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 43期

基金：

英国惠康基金;

关键词：

Trypanosoma brucei; cell-permeable glycosylphosphatidylinositol (GPI) analogues; African sleeping sickness; bioactivatable acetoxymethyl ester;

D O I：

10.1016/j.tetlet.2005.08.112

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of two cell-permeable analogues related to a GPI intermediate is described for studies with living trypano-somes and human (HeLa) cells. One of the analogues is metabolised by the former GPI pathway and is toxic to the parasite Try-panosoma brucei but not to human cells. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：7419 / 7421

页数：3

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