Immediate and delayed allergic hypersensitivity to corticosteroids: practical guidelines

被引：49
作者：
Baeck, Marie [1 ]
Goossens, An [2 ]
机构：
[1] Catholic Univ Louvain, Clin Univ St Luc, UCL, Dept Dermatol, B-1200 Brussels, Belgium
[2] Katholieke Univ Leuven, Univ Hosp, Dept Dermatol, B-3000 Louvain, Belgium
来源：
CONTACT DERMATITIS | 2012年 / 66卷 / 01期
关键词：
allergic contact dermatitis; corticosteroids; cross-reactions; delayed hypersensitivity; guidelines; immediate hypersensitivity; IGE-MEDIATED HYPERSENSITIVITY; CONTACT ALLERGY; CROSS-REACTIVITY; SKIN REACTIONS; ANAPHYLAXIS; DERMATITIS; BUDESONIDE; PATCH;
D O I：
10.1111/j.1600-0536.2011.01967.x
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Background. Corticosteroids (CS), anti-inflammatory drugs also widely used to treat various allergic diseases, may themselves give rise to immediate and delayed allergic hypersensitivity reactions. Objectives. To realise an appropriate diagnostic work-up in order to determine the CS-allergic patient's sensitization/ tolerance profile and define the potential replacement agents that can still be tolerated. Methods. Analysis of the patch test results and concomitant (cross-) reaction patterns obtained with 315 corticosteroid-allergic patients, as well as molecular modelling of molecules. Results. Proposal of a simplified classification of corticosteroids as to their allergenic properties into 3 groups, determination of two patient profiles according to steric and electrostatic properties of the molecules. Conclusion. Practical information to the medical profession in order to detect and manage such reactions is provided.
引用
收藏
页码：38 / 45
页数：8
相关论文
共 39 条
  • [1] IgE-mediated hypersensitivity reactions to methylprednisolone
    Aranda, A.
    Mayorga, C.
    Ariza, A.
    Dona, I.
    Blanca-Lopez, N.
    Canto, G.
    Blanca, M.
    Torres, M. J.
    [J]. ALLERGY, 2010, 65 (11) : 1376 - 1380
  • [2] Allergic hypersensitivity to topical and systemic corticosteroids: a review
    Baeck, M.
    Marot, L.
    Nicolas, J. -F.
    Pilette, C.
    Tennstedt, D.
    Goossens, A.
    [J]. ALLERGY, 2009, 64 (07) : 978 - 994
  • [3] Baeck M, 2011, ALLERGY 0614, DOI [10.1111/j.1398-9995.2011.02666.x, DOI 10.1111/J.1398-9995.2011.02666.X]
  • [4] C16-methyl corticosteroids are far less allergenic than the non-methylated molecules
    Baeck, Marie
    Chemelle, Julie-Anne
    Rasse, Catherine
    Terreux, Raphael
    Goossens, An
    [J]. CONTACT DERMATITIS, 2011, 64 (06) : 305 - 312
  • [5] Allergic Contact Dermatitis Following Ocular Use of Corticosteroids
    Baeck, Marie
    De Potter, Patrick
    Goossens, An
    [J]. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 2011, 27 (01) : 83 - 92
  • [6] Allergic contact dermatitis to inhalation corticosteroids
    Baeck, Marie
    Pilette, Charles
    Drieghe, Jacques
    Goossens, An
    [J]. EUROPEAN JOURNAL OF DERMATOLOGY, 2010, 20 (01) : 102 - 108
  • [7] Delayed hypersensitivity to corticosteroids in a series of 315 patients: clinical data and patch test results
    Baeck, Marie
    Chemelle, Julie-Anne
    Terreux, Raphael
    Drieghe, Jacques
    Goossens, An
    [J]. CONTACT DERMATITIS, 2009, 61 (03) : 163 - 175
  • [8] Patients with airborne sensitization/contact dermatitis from budesonide-containing aerosols 'by proxy'
    Baeck, Marie
    Goossens, An
    [J]. CONTACT DERMATITIS, 2009, 61 (01) : 1 - 8
  • [9] Bennett M L, 2001, Am J Contact Dermat, V12, P193
  • [10] Oral prednisolone induced acute generalized exanthematous pustulosis due to corticosteroids of group A confirmed by epicutaneous testing and lymphocyte transformation tests
    Buettiker, U.
    Keller, M.
    Pichler, W. J.
    Braathen, L. R.
    Yawalkar, N.
    [J]. DERMATOLOGY, 2006, 213 (01) : 40 - 43
1234