Immediate and delayed allergic hypersensitivity to corticosteroids: practical guidelines

被引：50
作者：
Baeck, Marie [1 ]
Goossens, An [2 ]
机构：
[1] Catholic Univ Louvain, Clin Univ St Luc, UCL, Dept Dermatol, B-1200 Brussels, Belgium
[2] Katholieke Univ Leuven, Univ Hosp, Dept Dermatol, B-3000 Louvain, Belgium
来源：
CONTACT DERMATITIS | 2012年 / 66卷 / 01期
关键词：
allergic contact dermatitis; corticosteroids; cross-reactions; delayed hypersensitivity; guidelines; immediate hypersensitivity; IGE-MEDIATED HYPERSENSITIVITY; CONTACT ALLERGY; CROSS-REACTIVITY; SKIN REACTIONS; ANAPHYLAXIS; DERMATITIS; BUDESONIDE; PATCH;
D O I：
10.1111/j.1600-0536.2011.01967.x
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Background. Corticosteroids (CS), anti-inflammatory drugs also widely used to treat various allergic diseases, may themselves give rise to immediate and delayed allergic hypersensitivity reactions. Objectives. To realise an appropriate diagnostic work-up in order to determine the CS-allergic patient's sensitization/ tolerance profile and define the potential replacement agents that can still be tolerated. Methods. Analysis of the patch test results and concomitant (cross-) reaction patterns obtained with 315 corticosteroid-allergic patients, as well as molecular modelling of molecules. Results. Proposal of a simplified classification of corticosteroids as to their allergenic properties into 3 groups, determination of two patient profiles according to steric and electrostatic properties of the molecules. Conclusion. Practical information to the medical profession in order to detect and manage such reactions is provided.
引用
收藏
页码：38 / 45
页数：8
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