Changes in EEG complexity with electroconvulsive therapy in a patient with autism spectrum disorders: a multiscale entropy approach

被引:30
作者
Okazaki, Ryoko [1 ]
Takahashi, Tetsuya [1 ]
Ueno, Kanji [1 ]
Takahashi, Koichi [1 ]
Ishitobi, Makoto [2 ]
Kikuchi, Mitsuru [3 ]
Higashima, Masato [1 ]
Wada, Yuji [1 ]
机构
[1] Univ Fukui, Fac Med Sci, Dept Neuropsychiat, Eiheiji, Fukui 9101193, Japan
[2] Natl Inst Mental Hlth, Natl Ctr Neurol & Psychiat, Dept Child & Adolescent Mental Hlth, Tokyo, Japan
[3] Kanazawa Univ, Res Ctr Child Mental Dev, Kanazawa, Ishikawa, Japan
基金
日本学术振兴会;
关键词
autism spectrum disorders; brain-derived neurotrophic factor; EEG complexity; electroconvulsive therapy; multiscale entropy; obsessive-compulsive disorder; PHYSIOLOGICAL TIME-SERIES; NEUROTROPHIC FACTOR; ALZHEIMERS-DISEASE; CATATONIA; PEOPLE; CONNECTIVITY; DYNAMICS; CHILDREN; SCALE; TASK;
D O I
10.3389/fnhum.2015.00106
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Autism spectrum disorders (ASD) are heterogeneous neurodevelopmental disorders that are reportedly characterized by aberrant neural networks. Recently developed multiscale entropy analysis (MSE) can characterize the complexity inherent in electroencephalography (EEG) dynamics over multiple temporal scales in the dynamics of neural networks. We encountered an 18-year-old man with ASD whose refractory catatonic obsessive-compulsive symptoms were improved dramatically after electroconvulsive therapy (ECT). In this clinical case study, we strove to clarify the neurophysiological mechanism of ECT in ASD by assessing EEG complexity using MSE. Along with ECT, the frontocentral region showed decreased EEG complexity at higher temporal scales, whereas the occipital region expressed an increase at lower temporal scales. Furthermore, these changes were associated with clinical improvement associated with the elevation of brain-derived neurotrophic factor, which is a molecular hypothesis of ECT, playing key roles in ASD pathogenesis. Changes in EEG complexity in a region-specific and temporal scale-specific manner that we found might reflect atypical EEG dynamics in ASD. Although MSE is not a direct approach to measuring neural connectivity and the results are from only a single case, they might reflect specific aberrant neural network activity and the therapeutic neurophysiological mechanism of ECT in ASD.
引用
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页数:7
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