Amazonian Fruit Mari-Mari (Cassia leiandra Benth.): Identification of Flavonoids and Antioxidant, Antimicrobial and Antiproliferative Properties

被引：1

作者：

Souza, Mayane P. de ^{[1
]}

Sa, Ingrity Suelen C. ^{[1
]}

Freitas, Flavio Augusto de

Souza, Afonso D. L. de ^{[1
]}

Nunomura, Sergio M. ^{[2
]}

Muniz, Magno P. ^{[2
]}

Pereira, Ana Paula R. ^{[3
]}

Augusto, Bianca O.

Gomes, Giovana B. ^{[4
,5
]}

Perdomo, Renata T. ^{[4
,5
]}

Macedo, Maria Ligia R. ^{[3
]}

Weber, Simone S.

Nunomura, Rita de Cassia S. ^{[1
]}

机构：

[1] Univ Fed Amazonas, Dept Quim, BR-69077000 Manaus, AM, Brazil

[2] Inst Nacl de Pesquisas da Amazonia, Coordenacao Tecnol & Inovacao, BR-69080971 Manaus, AM, Brazil

[3] Univ Fed Mato Grosso, Lab Purificacao Prot, E suas Funcoes Biol, BR-79070900 Campo Grande, MS, Brazil

[4] Univ Fed Mato Grosso do Sul, Fac Ciencias Farmaceut Alimentos & Nutricao, Lab Biociencias, BR-79070900 Campo Grande, MS, Brazil

[5] Univ Fed Mato Grosso do Sul, Fac Ciencias Farmaceut Alimentos & Nutricao, Programa Pos Graduacao Farm, BR-79070900 Campo Grande, MS, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 2022年

关键词：

Cassia leiandra; mari-mari; total phenolic contents; antioxidant property; cytotoxic activity; antimicrobial activity; ANTIBACTERIAL ACTIVITY; PHENOLIC-COMPOUNDS; ASTILBIN; ASSAY;

D O I：

10.21577/0103-5053.20220111

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mari-mari (Cassia leiandra Benth.) is an Amazonian native fruit that is highly appreciated in the northern region of Brazil, but there are few studies regarding its chemical composition and/or biological properties. A phytochemical study was conducted on the extracts of the pulp, peel and seeds; and their antioxidant, cytotoxic and antimicrobial potential were also determined. Methanol and acetone extracts from different fruit parts were subjected to total phenolic, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and FeIII reducing capacity (FRAP) assays. From the peel extracts, the engeletin and astilbin could also be isolated and characterized based on nuclear magnetic resonance spectroscopy and high-resolution mass spectrometry. A quantification using ultra-fast liquid chromatography of acetone dry crude extracts (DCE) of the peel showed that engeletin was the main compound (532.77 mg g-1 DCE). Astilbin content was also determined (131.53 mg g-1 DCE). The antibacterial and antiproliferative activities were evaluated and the methanol extract of the peel showed higher growth inhibition activity against all tested bacteria. Engeletin showed a relevant antimicrobial effect against Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli. Acetone and methanol peel extracts exhibited a relevant inhibitory effect on the proliferation of breast carcinoma cells (MCF-7), with no toxicity to the normal cell line (NIH/3T3).

引用

页码：325 / 332

页数：8