The origins of the trypanosome genome strains Trypanosoma brucei brucei TREU 927, T. b. gambiense DAL 972, T. vivax Y486 and T. congolense IL3000

被引:35
|
作者
Gibson, Wendy [1 ]
机构
[1] Univ Bristol, Sch Biol Sci, Bristol BS8 1UG, Avon, England
来源
PARASITES & VECTORS | 2012年 / 5卷
关键词
Trypanosomes; Pathogen; Genome; VARIANT SURFACE GLYCOPROTEIN; IN-VITRO CULTIVATION; DUTTONELLA VIVAX; TSETSE-FLIES; EAST-AFRICA; ENZYME POLYMORPHISM; GLOSSINA-PALLIDIPES; INVITRO CULTIVATION; SLEEPING SICKNESS; ANTIGEN GENE;
D O I
10.1186/1756-3305-5-71
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
The genomes of several tsetse-transmitted African trypanosomes (Trypanosoma brucei brucei, T. b. gambiense, T. vivax, T. congolense) have been sequenced and are available to search online. The trypanosome strains chosen for the genome sequencing projects were selected because they had been well characterised in the laboratory, but all were isolated several decades ago. The purpose of this short review is to provide some background information on the origins and biological characterisation of these strains as a source of reference for future users of the genome data. With high throughput sequencing of many more trypanosome genomes in prospect, it is important to understand the phylogenetic relationships of the genome strains.
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页数:6
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