Selecting patients for gastrectomy in metastatic esophago-gastric cancer: clinics and pathology are not enough

被引：13

作者：

Fornaro, Lorenzo ^{[1
]}

Fanotto, Valentina ^{[2
]}

Musettini, Gianna ^{[1
]}

Uccello, Mario ^{[3
]}

Rimassa, Lorenza ^{[4
]}

Vivaldi, Caterina ^{[1
]}

Fontanella, Caterina ^{[2
]}

Leone, Francesco ^{[5
]}

Giampieri, Riccardo ^{[6
]}

Rosati, Gerardo ^{[7
]}

Lencioni, Monica ^{[1
]}

Santini, Daniele ^{[8
]}

Di Donato, Samantha ^{[9
]}

Tomasello, Gianluca ^{[10
]}

Brunetti, Oronzo ^{[11
]}

Pietrantonio, Filippo ^{[12
]}

Bergamo, Francesca ^{[13
]}

Scartozzi, Mario ^{[14
]}

Avallone, Antonio ^{[15
]}

Lutrino, Stefania Eufemia ^{[16
]}

Melisi, Davide ^{[17
]}

Antonuzzo, Lorenzo ^{[18
]}

Pellegrino, Antonio ^{[19
]}

Gerratana, Lorenzo ^{[2
]}

Cordio, Stefano ^{[3
]}

Vasile, Enrico ^{[1
]}

Aprile, Giuseppe ^{[2
,20
]}

机构：

[1] Azienda Osped Univ Pisana, Unit Med Oncol 2, I-56126 Pisa, Italy

[2] Univ & Gen Hosp, Dept Oncol, I-33100 Udine, Italy

[3] Garibaldi Nesima Hosp, Dept Oncol, I-95122 Catania, Italy

[4] Humanitas Clin & Res Ctr, Humanitas Canc Ctr, Med Oncol & Hematol Unit, I-20089 Rozzano, MI, Italy

[5] IRCCS, Inst Canc Res & Treatment, I-10060 Candiolo, TO, Italy

[6] Osped Riuniti, Unit Med Oncol, I-60126 Ancona, Italy

[7] San Carlo Hosp, Unit Med Oncol, I-85100 Potenza, Italy

[8] Campus Biomed Univ, Med Oncol, I-00128 Rome, Italy

[9] Gen Hosp, Dept Med Oncol, I-59100 Prato, Italy

[10] Ist Ospitalieri Cremona, Med Oncol Div, I-26100 Cremona, Italy

[11] Natl Canc Inst IRCCS Giovanni Paolo II, Unit Med Oncol, I-70124 Bari, Italy

[12] Natl Canc Inst IRCCS, Med Oncol, I-20133 Milan, Italy

[13] IOV IRCCS, Med Oncol, I-35128 Padua, Italy

[14] Univ Cagliari, Univ Hosp, Unit Med Oncol, I-09124 Cagliari, Italy

[15] IRCCS Fdn G Pascale, Natl Canc Inst, Gastrointestinal Oncol, I-80131 Naples, Italy

[16] Perrino Hosp, Unit Med Oncol, I-72100 Brindisi, Italy

[17] Univ Verona, Unit Med Oncol, I-37126 Verona, Italy

[18] Careggi Univ Hosp, Unit Med Oncol, I-50134 Florence, Italy

[19] Vito Fazzi Hosp, Unit Oncol, I-73100 Lecce, Italy

[20] ULSS 8 Berica East Dist, San Bortolo Gen Hosp, Dept Oncol, I-36100 Vicenza, Italy

来源：

FUTURE ONCOLOGY | 2017年 / 13卷 / 25期

关键词：

chemotherapy; metastatic gastric cancer; palliative gastrectomy; GASTRIC-CANCER; PALLIATIVE RESECTION; DOUBLE-BLIND; CHEMOTHERAPY; SURGERY; ADENOCARCINOMA; PHASE-3; GUIDELINES;

D O I：

10.2217/fon-2017-0246

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To evaluate the impact on overall survival (OS) of gastrectomy in asymptomatic metastaticesophago-gastriccancer.Patients&methods: Five hundred and thirteen patients were included. The role of surgery and other clinico-pathological factors was evaluated by univariate and Cox regression analyses. OS was the primary end point. Results: Multivariate analysis confirmed that gastrectomy was a predictor of longer OS (p < 0.001), as well as preserved performance status and benefit from first-line chemotherapy. None of the investigated clinico-pathological variables identified preferable candidates for surgery (all p > 0.05). Conclusion: Palliative gastrectomy might play a role in asymptomatic metastatic esophago-gastric cancer patients with good performance status who received benefit from first-line chemotherapy. Future prospective trials integrating tumor biology among inclusion criteria may help defining the optimal candidates.

引用

页码：2265 / 2275

页数：11

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