RETRACTED: Knockdown of SRPX2 inhibits the proliferation, migration, and invasion of prostate cancer cells through the PI3K/Akt/mTOR signaling pathway (Retracted Article)

被引：9
作者：
Hong, Xin [1 ]
Hong, Xingyu [1 ]
Zhao, Haomin [1 ]
He, Chengyan [1 ]
机构：
[1] Jilin Univ, China Japan Union Hosp, Dept Vasc Surg, Changchun 130033, Jilin, Peoples R China
来源：
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2019年 / 33卷 / 01期
关键词：
invasion; proliferation; prostate cancer; SRPX2; METASTASIS; ACTIVATION; MECHANISMS; EMT;
D O I：
10.1002/jbt.22237
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sushi repeat-containing protein X-linked 2 (SRPX2), a novel chondroitin sulfate proteoglycan, is reported to play a critical role in tumorigenesis. However, the expression and functional role of SRPX2 in prostate cancer have not been defined. Thus, the aim of this study was to investigate the expression and functional role of SRPX2 in human prostate cancer. Our results showed that the expression of SRPX2 was obviously increased in human prostate cancer tissues and cell lines. In addition, knockdown of SRPX2 inhibited the proliferation, migration, and invasion of prostate cancer cells, as well as prevented the epithelial-mesenchymal transition process in prostate cancer cells. Mechanically, knockdown of SRPX2 efficiently inhibited the activation of PI3K/Akt/mTOR pathway in prostate cancer cells. Taken together, these data demonstrated that knockdown of SRPX2 inhibits the proliferation and metastasis in human prostate cancer cells, partly through the PI3K/Akt/mTOR signaling pathway. Thus, SRPX2 may be a novel therapeutic target for the treatment of prostate cancer.
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页数：7
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