RETRACTED: Knockdown of SRPX2 inhibits the proliferation, migration, and invasion of prostate cancer cells through the PI3K/Akt/mTOR signaling pathway (Retracted Article)

被引：9

作者：

Hong, Xin ^{[1
]}

Hong, Xingyu ^{[1
]}

Zhao, Haomin ^{[1
]}

He, Chengyan ^{[1
]}

机构：

[1] Jilin Univ, China Japan Union Hosp, Dept Vasc Surg, Changchun 130033, Jilin, Peoples R China

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2019年 / 33卷 / 01期

关键词：

invasion; proliferation; prostate cancer; SRPX2; METASTASIS; ACTIVATION; MECHANISMS; EMT;

D O I：

10.1002/jbt.22237

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sushi repeat-containing protein X-linked 2 (SRPX2), a novel chondroitin sulfate proteoglycan, is reported to play a critical role in tumorigenesis. However, the expression and functional role of SRPX2 in prostate cancer have not been defined. Thus, the aim of this study was to investigate the expression and functional role of SRPX2 in human prostate cancer. Our results showed that the expression of SRPX2 was obviously increased in human prostate cancer tissues and cell lines. In addition, knockdown of SRPX2 inhibited the proliferation, migration, and invasion of prostate cancer cells, as well as prevented the epithelial-mesenchymal transition process in prostate cancer cells. Mechanically, knockdown of SRPX2 efficiently inhibited the activation of PI3K/Akt/mTOR pathway in prostate cancer cells. Taken together, these data demonstrated that knockdown of SRPX2 inhibits the proliferation and metastasis in human prostate cancer cells, partly through the PI3K/Akt/mTOR signaling pathway. Thus, SRPX2 may be a novel therapeutic target for the treatment of prostate cancer.

引用

页数：7

共 50 条

[31] KIFC3 Promotes Proliferation, Migration, and Invasion in Colorectal Cancer via PI3K/AKT/mTOR Signaling Pathway [J].

Liao, Huiling ;

Zhang, Lan ;

Lu, Shimin ;

Li, Wei ;

Dong, Weiguo .

FRONTIERS IN GENETICS, 2022, 13

[32] RETRACTED: miR-217 inhibits proliferation, migration, and invasion via targeting AKT3 in thyroid cancer (Retracted Article) [J].

Lin, Yuanqiang ;

Cheng, Kailiang ;

Wang, Tongtong ;

Xie, Qian ;

Chen, Minglong ;

Chen, Qianqian ;

Wen, Qiang .

BIOMEDICINE & PHARMACOTHERAPY, 2017, 95 :1718-1724

[33] Lycium barbarum Polysaccharide (LBP) Inhibits Breast Cancer Migration and Invasion Through PI3K/AKT/mTOR Signaling Pathway [J].

Gong, Liyan ;

Cai, Hu ;

Zhou, Qinfei ;

Kong, Xiangming .

LATIN AMERICAN JOURNAL OF PHARMACY, 2018, 37 (05) :922-929

[34] Acetylshikonin inhibits the migration and invasion of A375 cells by reversing EMT process via the PI3K/Akt/mTOR pathway [J].

Jiang, Shuang ;

Wang, Haotian ;

Guo, Yan ;

Liu, Zhi ;

Song, Wu .

BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, 2019, 33 (01) :699-706

[35] RETRACTED: MicroRNA-145 inhibits the activation of the mTOR signaling pathway to suppress the proliferation and invasion of invasive pituitary adenoma cells by targeting AKT3 in vivo and in vitro (Retracted Article) [J].

Zhou, Kai ;

Fan, Yan-Dong ;

Wu, Peng-Fei ;

Duysenbi, Serick ;

Feng, Zhao-Hai ;

Du, Guo-Jia ;

Zhang, Ting-Rong .

ONCOTARGETS AND THERAPY, 2017, 10 :1625-1635

[36] RETRACTED: MicroRNA-99b suppresses human cervical cancer cell activity by inhibiting the PI3K/AKT/mTOR signaling pathway (Retracted Article) [J].

Li, Yong-Jie ;

Wang, Yue ;

Wang, Yi-Ying .

JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (06) :9577-9591

[37] RETRACTED: Knockdown of lncRNA MNX1-AS1 suppresses cell proliferation, migration, and invasion in prostate cancer (Retracted Article) [J].

Li, Zongwu ;

Wang, Fangfei ;

Zhang, Shibao .

FEBS OPEN BIO, 2019, 9 (05) :851-858

[38] RETRACTED: miR-135a Inhibits the Invasion and Migration of Esophageal Cancer Stem Cells through the Hedgehog Signaling Pathway by Targeting Smo (Retracted Article) [J].

Yang, Chengliang ;

Zheng, Xiaoli ;

Ye, Ke ;

Sun, Yanan ;

Lu, Yufei ;

Fan, Qingxia ;

Ge, Hong .

MOLECULAR THERAPY NUCLEIC ACIDS, 2020, 19 :841-852

[39] SOX2 knockdown inhibits the migration and invasion of basal cell carcinoma cells by targeting the SRPK1-mediated PI3K/AKT signaling pathway [J].

Li, Zhuo-Ran ;

Jiang, Yong ;

Hu, Jian-Zhong ;

Chen, Yang ;

Liu, Quan-Zhong .

ONCOLOGY LETTERS, 2019, 17 (02) :1617-1625

[40] Xanthine negatively regulates c-MYC through the PI3K/AKT signaling pathway and inhibits the proliferation, invasion, and migration of breast cancer cells [J].

Zhang, Aijia ;

Ai, Limei .

ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2025, 21 (01) :3-11

← 1 2 3 4 5 →