Suppression of antigen presentation by IL-10

被引：212
|
作者：
Mittal, Sharad K. [1 ]
Roche, Paul A. [1 ]
机构：
[1] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2015年 / 34卷
基金：
美国国家卫生研究院;
关键词：
MHC CLASS-II; DENDRITIC CELLS; ANTIINFLAMMATORY RESPONSE; TYROSINE PHOSPHORYLATION; NEGATIVE REGULATION; PEPTIDE COMPLEXES; INTERFERON-GAMMA; INDUCED GENES; ACTIVATION; EXPRESSION;
D O I：
10.1016/j.coi.2014.12.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Regulated antigen presentation to immune cells determines the effectiveness of an immune response. IL-10 is an immunosuppressive cytokine that regulates immune responses by inhibiting the ability of APCs to present antigens to T cells in a variety of ways. The mechanisms of IL-10-mediated immunosuppression include interference in TLR-mediated or IFN gamma-mediated dendritic cell (DC) and macrophage activation as well as direct induction of genes that suppress APC function. In this review we will discuss current studies exploring the molecular mechanisms by which IL-10 suppresses APC function.
引用
收藏
页码：22 / 27
页数：6
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