MicroRNAs in prostate cancer: Functional role as biomarkers

被引：123
作者：
Kanwal, Rajnee [1 ,2 ,3 ]
Plaga, Alexis R. [4 ,5 ]
Liu, Xiaoqi [6 ]
Shukla, Girish C. [4 ,5 ]
Gupta, Sanjay [1 ,2 ,3 ,7 ,8 ]
机构：
[1] Case Western Reserve Univ, Sch Med, Dept Urol, Cleveland, OH 44106 USA
[2] Univ Hosp Cleveland, Med Ctr, Urol Inst, Cleveland, OH 44106 USA
[3] Louis Stokes Cleveland Vet Affairs Med Ctr, Dept Urol, Cleveland, OH 44106 USA
[4] Cleveland State Univ, Ctr Gene Regulat Hlth & Dis, Cleveland, OH 44115 USA
[5] Cleveland State Univ, Dept Biol Sci, Cleveland, OH 44115 USA
[6] Purdue Univ, Dept Biochem, W Lafayette, IN 47907 USA
[7] Case Western Reserve Univ, Dept Nutr, Cleveland, OH 44106 USA
[8] Case Comprehens Canc Ctr, Div Gen Med Sci, Cleveland, OH 44106 USA
来源：
CANCER LETTERS | 2017年 / 407卷
关键词：
Non-coding RNA; Biomarkers; Oncomirs; Tumor suppressor; Androgen receptor; Castrate-resistant prostate cancer; EPITHELIAL-MESENCHYMAL TRANSITION; SUPPRESSES CELL-PROLIFERATION; TUMOR-SUPPRESSOR; ANDROGEN RECEPTOR; DOWN-REGULATION; BIOCHEMICAL RECURRENCE; CIRCULATING MICRORNAS; BONE METASTASIS; NONCODING RNAS; HEPATOCELLULAR-CARCINOMA;
D O I：
10.1016/j.canlet.2017.08.011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene expression through post-transcriptional regulation of messenger RNA. Compelling evidence suggest the role of miRNA in cancer biology having potential as diagnostic, prognostic and predictive biomarkers. This review summarizes the current knowledge on miRNA deregulated in prostate cancer and their role as oncogene, tumor suppressor and metastasis regulators. The emerging information elucidating the biological function of miRNA is promising and may lead to their potential usefulness as diagnostic/prognostic markers and development as effective therapeutic tools for management of prostate cancer. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：9 / 20
页数：12
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