Noninvasive theranostic imaging of HSV-TK/GCV suicide gene therapy in liver cancer by folate-targeted quantum dot-based liposomes

被引：53

作者：

Shao, Dan ^{[1
]}

Li, Jing ^{[1
]}

Pan, Yue ^{[1
]}

Zhang, Xin ^{[1
]}

Zheng, Xiao ^{[1
]}

Wang, Zheng ^{[1
]}

Zhang, Ming ^{[1
]}

Zhang, Hong ^{[2
]}

Chen, Li ^{[1
,3
]}

机构：

[1] Jilin Univ, Coll Basic Med Sci, Nanomed Engn Lab Jilin Prov, Dept Pharmacol, Changchun 130021, Peoples R China

[2] Univ Amsterdam, Vant Hoff Inst Mol Sci, NL-1098 XH Amsterdam, Netherlands

[3] Jilin Univ, Sch Nursing, Changchun 130021, Peoples R China

来源：

BIOMATERIALS SCIENCE | 2015年 / 3卷 / 06期

基金：

中国国家自然科学基金;

关键词：

HUMAN HEPATOCELLULAR-CARCINOMA; THYMIDINE KINASE; IN-VIVO; CATIONIC LIPOSOMES; IMMUNE-RESPONSES; DELIVERY-SYSTEM; OVARIAN-CANCER; PLASMID DNA; CELLS; NANOMEDICINE;

D O I：

10.1039/c5bm00077g

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Theranostics is emerging as a popular strategy for cancer therapy; thanks to the development of nano-technology. In this work, we have combined an HSV-TK/GCV suicide gene system and near-infrared quantum dots, as the former is quite effective in liver cancer treatment and the latter facilitates tumor imaging. A folate-modified theranostic liposome (FL/QD-TK) was developed, which is composed of an HSV-TK suicide gene covalently coupling with near-infrared fluorescent CdSeTe/ZnS core/shell quantum dots. The liver cancer-targeting and biosafety of FL/QD-TK were studied in vitro and in vivo. FL/QD-TK exhibited highly specific tumor imaging and strong inhibition of the folate receptor-overexpressed Bel-7402 mouse xenografts without systematic toxicity. This study may shed light on gene delivery and targeted cancer therapy.

引用

页码：833 / 841

页数：9

共 4 条

[1] HSV-TK/GCV cancer suicide gene therapy by a designed recombinant multifunctional vector
Wang, Yuhua
Canine, Brenda F.
Hatefi, Arash
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2011, 7 (02) : 193 - 200
[2] An experimental study on cervix cancer with combination of HSV-TK/GCV suicide gene therapy system and 60Co radiotherapy
Chen, Daozhen
Tang, Qiusha
BMC CANCER, 2010, 10
[3] Bifidobacterium infantis-mediated HSV-TK/GCV suicide gene therapy induces both extrinsic and intrinsic apoptosis in a rat model of bladder cancer
Yin, X.
Yu, B.
Tang, Z.
He, B.
Ren, J.
Xiao, X.
Tang, W.
CANCER GENE THERAPY, 2013, 20 (02) : 77 - 81
[4] Monitoring HSV-TK/ganciclovir cancer suicide gene therapy using CdTe/CdS core/shell quantum dots
Shao, Dan
Zeng, Qinghui
Fan, Zheng
Li, Jing
Zhang, Ming
Zhang, Youlin
Li, Ou
Chen, Li
Kong, Xianggui
Zhang, Hong
BIOMATERIALS, 2012, 33 (17) : 4336 - 4344

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