Extracellular Vesicles and Alveolar Epithelial-Capillary Barrier Disruption in Acute Respiratory Distress Syndrome: Pathophysiological Role and Therapeutic Potential

被引：15
作者：
Esquivel-Ruiz, Sergio [1 ,2 ]
Gonzalez-Rodriguez, Paloma [2 ,3 ]
Lorente, Jose A. [2 ,3 ,4 ]
Perez-Vizcaino, Francisco [1 ,2 ]
Herrero, Raquel [2 ,3 ]
Moreno, Laura [1 ,2 ]
机构：
[1] Univ Complutense Madrid, Sch Med, Inst Invest Sanit Gregorio Maranon IiSGM, Dept Pharmacol & Toxicol, Madrid, Spain
[2] Ciber Enfermedades Resp CIBERES, Madrid, Spain
[3] Hosp Univ Getafe, Dept Crit Care, Madrid, Spain
[4] European Univ Madrid, Sch Med, Clin Sect, Madrid, Spain
来源：
FRONTIERS IN PHYSIOLOGY | 2021年 / 12卷
关键词：
barrier dysfunction; airway epithelium; pulmonary endothelium; mesenchymal stem cells; extracellular vesicles (EVs); preconditioning; MESENCHYMAL STEM-CELLS; ACUTE LUNG INJURY; TISSUE FACTOR ACTIVITY; DISSEMINATED INTRAVASCULAR COAGULATION; NF-KAPPA-B; STROMAL CELLS; ENDOTHELIAL-CELLS; INTERFERON-GAMMA; FLUID CLEARANCE; IN-VITRO;
D O I：
10.3389/fphys.2021.752287
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Extracellular vesicles (EVs) mediate intercellular communication by transferring genetic material, proteins and organelles between different cells types in both health and disease. Recent evidence suggests that these vesicles, more than simply diagnostic markers, are key mediators of the pathophysiology of acute respiratory distress syndrome (ARDS) and other lung diseases. In this review, we will discuss the contribution of EVs released by pulmonary structural cells (alveolar epithelial and endothelial cells) and immune cells in these diseases, with particular attention to their ability to modulate inflammation and alveolar-capillary barrier disruption, a hallmark of ARDS. EVs also offer a unique opportunity to develop new therapeutics for the treatment of ARDS. Evidences supporting the ability of stem cell-derived EVs to attenuate the lung injury and ongoing strategies to improve their therapeutic potential are also discussed.
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页数：28
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