Necrotizing Hemorrhagic Gastritis following Acute Myeloid Leukemia Induction with Midostaurin: An Unexpected Complication

被引：4
|
作者：
Shimony, Shai [1 ,2 ]
Mintz, Hilla Reiss [3 ]
Beryozkin, Yulia Shvartser [4 ]
Shoham, Avivit [5 ]
Raanani, Pia [1 ,2 ]
Wolach, Ofir [1 ,2 ]
机构：
[1] Beilinson Med Ctr, Davidoff Canc Ctr, Inst Hematol, Rabin Med Ctr, Petah Tiqwa, Israel
[2] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
[3] Beilinson Med Ctr, Div Gastroenterol, Rabin Med Ctr, Petah Tiqwa, Israel
[4] Beilinson Med Ctr, Div Pathol, Rabin Med Ctr, Petah Tiqwa, Israel
[5] Beilinson Med Ctr, Radiol Dept, Rabin Med Ctr, Petah Tiqwa, Israel
来源：
ACTA HAEMATOLOGICA | 2020年 / 143卷 / 01期
关键词：
Acute myeloid leukemia; Midostaurin; Hemorrhagic gastritis;
D O I：
10.1159/000500975
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Midostaurin is a tyrosine multikinase inhibitor approved for the treatment of patients with newly diagnosed acute myeloid leukemia (AML) with mutated Fms-like tyrosine kinase-3. We describe a case report of a 49-year-old AML patient treated with an intensive chemotherapy regimen followed by midostaurin. After achieving complete remission with blood count recovery, he suffered from a serious, rare complication of necrotizing hemorrhagic gastritis with no evidence of infection or malignant infiltration, possibly associated with midostaurin therapy.
引用
收藏
页码：65 / 68
页数：4
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