Synthesis of 2,4,6-Trisubstituted Pyridines by Oxidative Eosin Y Photoredox Catalysis

被引：70

作者：

Rohokale, Rajendra S. ^{[1
]}

Koenig, Burkhard ^{[2
]}

Dhavale, Dilip D. ^{[1
]}

机构：

[1] Savitribai Phule Pune Univ, Garware Res Ctr, Dept Chem, Pune 411007, Maharashtra, India

[2] Univ Regensburg, Inst Organ Chem, Univ Str 31, D-93053 Regensburg, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 16期

关键词：

SOLVENT-FREE REACTION; ARYL DIAZONIUM SALTS; METAL-FREE; SUBSTITUTED PYRIDINES; EFFICIENT SYNTHESIS; 2,4,6-TRIARYLPYRIDINES; NITROGEN; LIGANDS; FUNCTIONALIZATION; ARYLATION;

D O I：

10.1021/acs.joc.6b00979

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Eosin Y, an organic dye, was activated as a photoredox catalyst in the presence of molecular oxygen using visible light and, when it was used in the reaction of aryl ketones and benzyl amines, afforded good yields (52-87%) of 2,4,6-triarylpyridines (21 examples) at ambient temperature. The aryl groups at the 2- and 6-positions are derived from ketones, while benzyl, amine plays the dual role of providing an aryl functionality at the 4-position of pyridine as well as being a nitrogen donor.

引用

页码：7121 / 7126

页数：6

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