HIV-1 Entry Inhibitors: A Review of Experimental and Computational Studies

被引：12

作者：

Rad, Tahereh Mostashari ^{[1
]}

Saghaie, Lotfollah ^{[1
]}

Fassihi, Afshin ^{[1
,2
]}

机构：

[1] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Med Chem, Esfahan 8174673461, Iran

[2] Isfahan Univ Med Sci, Sch Adv Technol Med, Bioinformat & Syst Biol Dept, Esfahan 8174673461, Iran

来源：

CHEMISTRY & BIODIVERSITY | 2018年 / 15卷 / 10期

关键词：

HIV-1-entry; anti-HIV agents; CCR5; CXCR4; gp41; gp120; SUBSTITUTED PYRROLE DERIVATIVES; SMALL-MOLECULE CD4-MIMICS; CCR5; ANTAGONISTS; BINDING-SITES; CD4; BINDING; RESISTANCE; DESIGN; GP120; POTENT; GP41;

D O I：

10.1002/cbdv.201800159

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The HIV-1 life cycle consists of different events, such as cell entry and fusion, virus replication, assembly and release of the newly formed virions. The more logical way to inhibit HIV transmission among individuals is to inhibit its entry into the immune host cells rather than targeting the intracellular viral enzymes. Both viral and host cell surface receptors and co-receptors are regarded as potential targets in anti-HIV-1 drug design process. Because of the importance of this topic it was decided to summarize recent reports on small-molecule HIV-1 entry inhibitors that have not been considered in the latest released reviews. All the computational studies reported in the literature regarding HIV-1 entry inhibitors since 2014 was also considered in this review.

引用

页数：19

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