The premetazoan ancestry of cadherins

被引：158

作者：

Abedin, Monika ^{[1
,2
]}

King, Nicole ^{[1
,2
,3
]}

机构：

[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Ctr Integrat Genom, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Integrat Genom, Berkeley, CA 94720 USA

来源：

SCIENCE | 2008年 / 319卷 / 5865期

关键词：

D O I：

10.1126/science.1151084

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cadherin- mediated cell adhesion and signaling is essential for metazoan development and yet is absent from all other multicellular organisms. We found cadherin genes at numbers similar to those observed in complex metazoans in one of the closest single- celled relatives of metazoans, the choanoflagellate Monosiga brevicollis. Because the evolution of metazoans from a single- celled ancestor required novel cell adhesion and signaling mechanisms, the discovery of diverse cadherins in choanoflagellates suggests that cadherins may have contributed to metazoan origins.

引用

页码：946 / 948

页数：3

共 33 条

[1] The evolutionary origin of hedgehog proteins [J].

Adamska, Maja ;

Matus, David Q. ;

Adamski, Marcin ;

Green, Kathryn ;

Rokhsar, Daniel S. ;

Martindale, Mark Q. ;

Degnan, Bernard M. .

CURRENT BIOLOGY, 2007, 17 (19) :R836-R837

[2]

Bateman A, 2002, NUCLEIC ACIDS RES, V30, P276, DOI [10.1093/nar/gkr1065, 10.1093/nar/gkp985, 10.1093/nar/gkh121]

[3] Flamingo cadherin:: A putative host receptor for Streptococcus pneumoniae [J].

Blau, Karin ;

Portnoi, Maxim ;

Shagan, Marilou ;

Kaganovich, Antonina ;

Rom, Slava ;

Kafka, Daniel ;

Caspi, Vered Chalifa ;

Porgador, Angel ;

Givon-Lavi, Noga ;

Gershoni, Jonathan M. ;

Dagan, Ron ;

Nebenzahl, Yaffa Mizrachi .

JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (12) :1828-1837

[4] Bacterial pathogenesis: exploiting cellular adherence [J].

Boyle, EC ;

Finlay, BB .

CURRENT OPINION IN CELL BIOLOGY, 2003, 15 (05) :633-639

[5] The evolution of multicellularity and early animal genomes [J].

Brooke, NM ;

Holland, PWH .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2003, 13 (06) :599-603

[6] Unique mitochondrial genome architecture in unicellular relatives of animals [J].

Burger, G ;

Forget, L ;

Zhu, Y ;

Gray, MW ;

Lang, BF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (03) :892-897

[7] Adhesion proteins and the control of cell shape [J].

Carthew, RW .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2005, 15 (04) :358-363

[8] Cadherin-mediated cell-cell adhesion and tissue segregation in relation to malignancy [J].

Foty, RA ;

Steinberg, MS .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2004, 48 (5-6) :397-409

[9] Regulation of cadherin-mediated adhesion in morphogenesis [J].

Gumbiner, BM .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (08) :622-634

[10] Regulation of cadherin adhesive activity [J].

Gumbiner, BM .

JOURNAL OF CELL BIOLOGY, 2000, 148 (03) :399-403

← 1 2 3 4 →