Naringin prevents carbon tetrachloride-induced acute liver injury in mice

被引：64

作者：

Dong, Deshi ^{[1
,2
]}

Xu, Lina ^{[1
]}

Yin, Lianhong ^{[1
]}

Qi, Yan ^{[1
]}

Peng, Jinyong ^{[1
]}

机构：

[1] Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China

[2] Dalian Med Univ, Affiliated Hosp 1, Dalian 116011, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2015年 / 12卷

关键词：

Acute liver injury; Carbon tetrachloride; Hepatoprotective effect; Naringin; HEPATIC ISCHEMIA/REPERFUSION INJURY; ACTIVATED PROTEIN-KINASE; INDUCED HEPATOTOXICITY; OXIDATIVE STRESS; SALVIA-MILTIORRHIZA; CYTOCHROME-C; DAMAGE; EXTRACT; RATS; MECHANISMS;

D O I：

10.1016/j.jff.2014.11.020

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The protective effects and mechanisms of action of naringin (Nar) against carbon tetrachloride (CCl4)-induced hepatic injury in mice were investigated. The results showed that oral administration of Nar significantly decreased the levels of alanine transaminase and alanine transaminase in serum, nitric oxide, inducible nitric oxide synthase and thiobarbituric acid reactive substances in hepatic tissue, and markedly increased the levels of superoxide dismutase, catalase, glutathione peroxidase and glutathione/oxidized glutathione ratio compared with the model group. Transmission electron microscopy and histopathology assay also showed the hepatoprotective effect of Nar against the damage. In addition, Nar markedly decreased cytochrome P4502E1 expression, suppressed oxidative stress, inflammation and apoptosis, and decreased phosphorylation levels of mitogen-activated protein kinases caused by CCl4. These results imply that Nar has perfect effect against CCl4-induced liver injury in mice, which should be developed as an effective food and healthcare product for the treatment of liver injury in the future. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：179 / 191

页数：13

共 65 条

[21] Redox regulation of pyo-inflammatory cytokines and IκB-α/NF-κB nuclear translocation and activation [J].

Haddad, JJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 296 (04) :847-856

[22] Protective effect of antrosterol from Antrodia camphorata submerged whole broth against carbon tetrachloride-induced acute liver injury in mice [J].

Huang, Guan-Jhong ;

Deng, Jeng-Shyan ;

Huang, Shyh-Shyun ;

Shao, Yi-Yuan ;

Chen, Chin-Chu ;

Kuo, Yueh-Hsiung .

FOOD CHEMISTRY, 2012, 132 (02) :709-716

[23] Protective effect of the Aralia continentalis root extract against carbon tetrachloride-induced hepatotoxicity in mice [J].

Hwang, Yong Pil ;

Choi, Jae Ho ;

Jeong, Hye Gwang .

FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (01) :75-81

[24] Activation of mitogen activated protein kinase (MAPK) during carbon tetrachloride intoxication in the rat liver [J].

Iida, Chinatsu ;

Fujii, Kozue ;

Kishioka, Terumi ;

Nagae, Ritsuko ;

Onishi, Yuki ;

Ichi, Ikuyo ;

Kojo, Shosuke .

ARCHIVES OF TOXICOLOGY, 2007, 81 (07) :489-493

[25] Modulation of radiation-induced alteration in the antioxidant status of mice by naringin [J].

Jagetia, GC ;

Reddy, TK .

LIFE SCIENCES, 2005, 77 (07) :780-794

[26] Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits [J].

Jeon, SM ;

Bok, SH ;

Jang, MK ;

Lee, MK ;

Nam, KT ;

Park, YB ;

Rhee, SJ ;

Choi, MS .

LIFE SCIENCES, 2001, 69 (24) :2855-2866

[27] Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells [J].

Jia, Yannan ;

Ji, Liu ;

Zhang, Shuai ;

Xu, Lina ;

Yin, Lianhong ;

Li, Lei ;

Zhao, Yanyan ;

Peng, Jinyong .

FOOD AND CHEMICAL TOXICOLOGY, 2012, 50 (09) :3133-3141

[28] Expression of Toll-like receptor 4 in rat liver during the course of carbon tetrachloride-induced liver injury [J].

Jing Hua ;

De Kai Qiu ;

Ji Qiang Li ;

Eng Lin Li ;

Xiao Yu Chen ;

Yan Sheng Peng .

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2007, 22 (06) :862-869

[29] Naringin supplementation lowers plasma lipids and enhances erythrocyte antioxidant enzyme activities in hypercholesterolemic subjects [J].

Jung, UJ ;

Kim, HJ ;

Lee, JS ;

Lee, MK ;

Kim, HO ;

Park, EJ ;

Kim, HK ;

Jeong, TS ;

Choi, MS .

CLINICAL NUTRITION, 2003, 22 (06) :561-568

[30] Apoptotic signaling in dopamine-induced cell death:: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases [J].

Junn, E ;

Mouradian, MM .

JOURNAL OF NEUROCHEMISTRY, 2001, 78 (02) :374-383

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