Naringin prevents carbon tetrachloride-induced acute liver injury in mice

被引：64
作者：
Dong, Deshi [1 ,2 ]
Xu, Lina [1 ]
Yin, Lianhong [1 ]
Qi, Yan [1 ]
Peng, Jinyong [1 ]
机构：
[1] Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China
[2] Dalian Med Univ, Affiliated Hosp 1, Dalian 116011, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2015年 / 12卷
关键词：
Acute liver injury; Carbon tetrachloride; Hepatoprotective effect; Naringin; HEPATIC ISCHEMIA/REPERFUSION INJURY; ACTIVATED PROTEIN-KINASE; INDUCED HEPATOTOXICITY; OXIDATIVE STRESS; SALVIA-MILTIORRHIZA; CYTOCHROME-C; DAMAGE; EXTRACT; RATS; MECHANISMS;
D O I：
10.1016/j.jff.2014.11.020
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The protective effects and mechanisms of action of naringin (Nar) against carbon tetrachloride (CCl4)-induced hepatic injury in mice were investigated. The results showed that oral administration of Nar significantly decreased the levels of alanine transaminase and alanine transaminase in serum, nitric oxide, inducible nitric oxide synthase and thiobarbituric acid reactive substances in hepatic tissue, and markedly increased the levels of superoxide dismutase, catalase, glutathione peroxidase and glutathione/oxidized glutathione ratio compared with the model group. Transmission electron microscopy and histopathology assay also showed the hepatoprotective effect of Nar against the damage. In addition, Nar markedly decreased cytochrome P4502E1 expression, suppressed oxidative stress, inflammation and apoptosis, and decreased phosphorylation levels of mitogen-activated protein kinases caused by CCl4. These results imply that Nar has perfect effect against CCl4-induced liver injury in mice, which should be developed as an effective food and healthcare product for the treatment of liver injury in the future. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：179 / 191
页数：13
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