YH25448, a Highly Selective 3rd Generation EGFR TKI, Exhibits Superior Survival over Osimertinib in Animal Model with Brain Metastases from NSCLC

被引：7

作者：

Hong, Min Hee ^{[1
]}

Lee, In Yong ^{[2
]}

Koh, Jong Sung ^{[2
]}

Lee, Jaekyoo ^{[2
]}

Suh, Byung-Chul ^{[2
]}

Song, Ho-Juhn ^{[2
]}

Salgaonkar, Paresh ^{[2
]}

Lee, Jaesang ^{[2
]}

Lee, Young -Sung ^{[3
]}

Oh, Se-Woong ^{[3
]}

Kim, Jong Kyun ^{[3
]}

Nam, Su Youn ^{[3
]}

Cho, Byoung Chul ^{[1
]}

机构：

[1] Yonsei Univ, Coll Med, Younsei Canc Ctr, Div Med Oncol, Seoul, South Korea

[2] Genosco Inc, Cambridge, MA USA

[3] Yuhan Corp, Yuhan R&d Inst, Yongin, South Korea

来源：

关键词：

YH25448; 3rd generation EGFR TKI; brain metastases; BBB; T790M mutation; mouse model;

D O I：

10.1016/j.jtho.2016.11.1787

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

P3.02b-119

引用

页码：S1265 / S1266

页数：2