The Dynamics of Apoptotic Cell Clearance

被引：230
作者：
Elliott, Michael R. [1 ,2 ]
Ravichandran, Kodi S. [3 ,4 ,5 ]
机构：
[1] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol, Rochester, NY 14642 USA
[2] Univ Rochester, Sch Med & Dent, David H Smith Ctr Vaccine Biol & Immunol, Rochester, NY 14642 USA
[3] Univ Virginia, Dept Microbiol, Immunol, Canc Biol, Charlottesville, VA 22908 USA
[4] Univ Virginia, Beirne B Carter Ctr Immunol Res, Charlottesville, VA 22908 USA
[5] Univ Virginia, Ctr Cell Clearance, Charlottesville, VA 22908 USA
来源：
DEVELOPMENTAL CELL | 2016年 / 38卷 / 02期
关键词：
RECEPTOR TYROSINE KINASE; FIND-ME SIGNALS; PHOSPHATIDYLSERINE RECEPTOR; NEUTROPHIL RECRUITMENT; DIRECTIONAL MIGRATION; SURFACE CALRETICULIN; ENGULFMENT RECEPTOR; SPERMATOGENIC CELLS; NEGATIVE SELECTION; HUMAN MACROPHAGES;
D O I：
10.1016/j.devcel.2016.06.029
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live-imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.
引用
收藏
页码：147 / 160
页数：14
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