4-Dimethylaminopyridine-catalyzed [3+3] spiroannulation reactions of isatin-derived Morita-Baylis-Hillman carbonates with indoline-2-thiones

被引：12

作者：

Geng, Congcong ^{[1
]}

Wei, Xingfu ^{[1
]}

Xu, Yongqiang ^{[1
]}

Liu, Jianhui ^{[1
]}

Peng, Lizeng ^{[2
]}

Wang, Baomin ^{[1
]}

机构：

[1] Dalian Univ Technol, Dept Pharmaceut Sci, State Key Lab Fine Chem, Dalian 116024, Peoples R China

[2] Shandong Acad Agr Sci, Jinan 250100, Peoples R China

来源：

TETRAHEDRON LETTERS | 2022年 / 102卷

关键词：

Spiroannulations; DMAP; Morita -Baylis -Hillman carbonates; Sulfur heterocycles; ANNULATED SULFUR HETEROCYCLES; STEREOSELECTIVE-SYNTHESIS; CONSTRUCTION; DERIVATIVES; ALKYLATION; ACCESS; THIOPYRANO; SKELETONS; OXINDOLES; ADDUCTS;

D O I：

10.1016/j.tetlet.2022.153950

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

DMAP-catalyzed diastereoselective [3 + 3] spiroannulations of isatin-derived Morita-Baylis-Hillman car-bonates with indoline-2-thiones were achieved. A series of bisindole-annulated thiopyran frameworks were synthesized in good yields with good diastereoselectivities. The strategy developed in this paper offered a novel way for the synthesis of valuable indole-annulated sulfur heterocycle derivatives which might be beneficial in organic synthesis and medicinal chemistry. (c) 2022 Elsevier Ltd. All rights reserved.

引用

页数：4

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