EFFICIENT SYNTHESIS AND ANTICANCER ACTIVITIES OF SOME NOVEL FUNCTIONALIZED (4-OXO-4H-CHROMEN-3-YL)2-SELENOXO-1,2-DIHYDROPYRIMIDINES

被引：2

作者：

Ali, Tarik E. ^{[1
,2
]}

Assiri, Mohammed A. ^{[1
]}

Ali, Mamdouh M. ^{[3
]}

Ali, Abeer E. M. ^{[3
]}

Yahia, Ibrahim S. ^{[4
,5
,6
]}

Zahran, Heba Y. ^{[4
,5
,6
]}

机构：

[1] King Khalid Univ, Fac Sci, Dept Chem, Abha, Saudi Arabia

[2] Ain Shams Univ, Fac Educ, Dept Chem, Cairo, Egypt

[3] Natl Res Ctr, Genet Engn & Biotechnol Div, Biochem Dept, Giza, Egypt

[4] King Khalid Univ, Res Ctr Adv Mat Sci RCAMS, Abha, Saudi Arabia

[5] King Khalid Univ, Fac Sci, Dept Phys, Abha, Saudi Arabia

[6] Ain Shams Univ, Fac Educ, Dept Phys, Cairo, Egypt

来源：

HETEROCYCLES | 2020年 / 100卷 / 11期

关键词：

Chromone; Selenium; Pyrimidine; Anticancer Activity; CHROMONES; APOPTOSIS; ANTIOXIDANT; CATALYST; CELLS;

D O I：

10.3987/COM-20-14324

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Some novel functionalized 2-selenoxo-1,2-dihydropyrimidines bearing a chromone ring 2a-h were synthesized in excellent yields via a simple one-pot reaction. The simple method depended on one-pot three-component the reaction of 3-formylchromone (1) and selenourea with some active methylene compounds in the presence of sodium benzoate as a basic catalyst in a mixture of ethanol and water. The reactions were completed in 1.5-2.5 h in 88-94% yields. Structures of the synthesized compounds were based on elemental analysis, IR, H-1- and C-13-NMR and mass spectrometry. The anticancer properties of the synthesized compounds were evaluated against five cancer cell lines. Compounds 2a-d displayed the most potent anticancer activities against A549, MCF-7 and HepG2 cell lines in comparison with doxorubicin as the standard drug.

引用

页码：1831 / 1844

页数：14

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