Inclusion complexation with cyclodextrins

被引：0

作者：

Klein, CT ^{[1
]}

Viernstein, H ^{[1
]}

Wolschann, P ^{[1
]}

机构：

[1] Inst Theoret Chem & Mol Strukturbiol, A-1090 Vienna, Austria

来源：

MINERVA BIOTECNOLOGICA | 2000年 / 12卷 / 04期

关键词：

cyclodextrin; inclusion complexes; encapsulation; triflumizole; QSAR; bioavailability;

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Inclusion of guest molecules into the hydrophobic cavity of various cyclodextrins changes the properties of these guest molecules, which can be used for a broad variety of applications. Prediction models obtained from QSAR studies lead to a better understanding of the inclusion mechanism. A special feature of such complexation is the enthalpy-entropy compensation and pronounced solubility enhancements, which are used for better bioavailabilty of drugs and, in the case of biocides for a reduction of the biologically active compounds by equal activity.

引用

页码：287 / 292

页数：6

共 50 条

[21] Inclusion complexation of furosemide in cyclodextrins - Part 1: Effect of cyclodextrins on the physicochemical characteristics of furosemide
Ammar, HO
Ghorab, M
El-Nahhas, SA
Emara, LH
Makram, TS
PHARMAZIE, 1999, 54 (02): : 142 - 144
[22] Effect of Trimethoprim Inclusion Complexation with Cyclodextrins on its Antimicrobial Activity
Chandurkar, Pranjali W.
Shinde, Tushar A.
Akarte, Anup M.
Raichurkar, P. P.
CHEMICAL METHODOLOGIES, 2019, 3 (02): : 211 - 225
[23] Inclusion complexation of tolfenamic acid with β-cyclodextrins and its formulation into tablets
Vavia, PR
Adhage, NA
PROCEEDINGS OF THE 9TH INTERNATIONAL SYMPOSIUM ON CYCLODEXTRINS, 1999, : 479 - 482
[24] Inclusion complexation of diazepam with different cyclodextrins in formulations for parenteral use
Holvoet, C
Vander Heyden, Y
Plaizier-Vercammen, J
PHARMAZIE, 2005, 60 (08): : 598 - 603
[25] A theoretical study on the inclusion complexation of cyclodextrins with inorganic cations and anions
Fu, Y
Liu, L
Guo, QX
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2002, 43 (3-4) : 223 - 229
[26] Effects of humic acids on the inclusion complexation of cyclodextrins with organophosphorus pesticides
Ishiwata, S
Kamiya, M
CHEMOSPHERE, 1999, 38 (10) : 2219 - 2226
[27] Inclusion complexation of sulfapyridine with α- and β-cyclodextrins: Spectral and molecular modeling study
Rajendiran, N.
Siva, S.
Saravanan, J.
JOURNAL OF MOLECULAR STRUCTURE, 2013, 1054 : 215 - 222
[28] Improved oral bioavailability of artemisinin through inclusion complexation with β- and γ-cyclodextrins
Wong, JW
Yuen, KH
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2001, 227 (1-2) : 177 - 185
[29] Effects of substituent and solvent on inclusion complexation of β-cyclodextrins with azobenzene derivatives
Sueishi, Y
Kasahara, M
Inoue, M
Matsueda, K
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, 2003, 46 (1-2) : 71 - 75
[30] A theoretical study on the inclusion complexation of cyclodextrins with radical cations and anions
Mu, TW
Liu, L
Li, XS
Guo, QX
JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 2001, 14 (08) : 559 - 565

← 1 2 3 4 5 →