Regioselective one-pot synthesis of 9-alkyl-6-chloropyrido[3,2-e][1,2,4]triazolo-[4,3-a]pyrazines.: Reactivity of aliphatic and aromatic hydrazides

被引：21
作者：
Unciti-Broceta, A
Pineda-de-las-Infantas, MJ
Díaz-Mochón, JJ
Romagnoli, R
Baraldi, PG
Gallo, MA
Espinosa, A
机构：
[1] Univ Granada, Fac Farm, Dept Quim Farmaceut & Organ, E-18071 Granada, Spain
[2] Dipartimento Sci Farmaceut, I-44100 Ferrara, Italy
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 07期
关键词：
D O I：
10.1021/jo0478398
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The one-pot synthesis of new 9-alkyl-6-chloropyrido [3,2-e] [1,2,4]triazolo[4,3-alpha]alpyrazines has been achieved. Hydrazides regioselectively reacted as nucleophiles with the 3-chloro substituent of 2,3-dichloropyrido[2,3-b]pyrazine. An intramolecular cyclization afforded the tricycle nonxanthine adenosine receptor antagonists.
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页码：2878 / 2880
页数：3
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