Bullous pemphigoid-like skin blistering disease in a rhesus macaque (Macaca mulatta)

被引：1

作者：

Kim, Jong-Min ^{[1
,2
]}

Kim, Hyun-Je ^{[1
,3
,4
,5
]}

Min, Byoung-Hoon ^{[1
,3
,4
]}

Shin, Jun-Seop ^{[1
,2
,3
,4
,6
]}

Jeong, Won Young ^{[1
]}

Lee, Ga Eul ^{[1
]}

Kim, Min Sun ^{[1
]}

Kim, Ju Eun ^{[1
]}

Park, Chung-Gyu ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Seoul Natl Univ, Grad Sch, Xenotransplantat Res Ctr, Seoul, South Korea

[2] Seoul Natl Univ, Grad Sch, Inst Endem Dis, Seoul, South Korea

[3] Seoul Natl Univ, Grad Sch, Dept Microbiol & Immunol, Seoul, South Korea

[4] Seoul Natl Univ, Grad Sch, Canc Res Inst, Seoul, South Korea

[5] Seoul Natl Univ, Grad Sch, Dept Biomed Sci, Seoul, South Korea

[6] Seoul Natl Univ Hosp, Biomed Res Inst, Seoul, South Korea

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 2016年 / 45卷 / 04期

关键词：

bullous pemphigoid; rhesus monkey; skin; LINEAR IGA DISEASE; ERYTHEMA MULTIFORME; MUCOSAL INVOLVEMENT; VULGARIS; AUTOANTIBODIES; ANTIGENS;

D O I：

10.1111/jmp.12225

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Autoimmune bullous disease is very uncommon in non-human primates. We observed a bullous skin disease in a male rhesus monkey while conducting porcine islet xenotransplantation. Fifty days after the transplantation, multiple bullous skin lesions were observed. There was no mucosal involvement. Skin biopsy results demonstrated a subepidermal blister with no necrotic keratinocytes. Immunofluorescent staining showed linear IgG deposition at the roof of the blister. These skin lesions spontaneously disappeared. Considering these results, this monkey was diagnosed with bullous pemphigoid (BP). As far as we know, this is the first report of BP in non-human primates.

引用

页码：206 / 208

页数：3

共 20 条

[1] AUTOANTIBODIES AGAINST A NOVEL EPITHELIAL CADHERIN IN PEMPHIGUS-VULGARIS, A DISEASE OF CELL-ADHESION [J].

AMAGAI, M ;

KLAUSKOVTUN, V ;

STANLEY, JR .

CELL, 1991, 67 (05) :869-877

[2] Pemphigus vulgaris antigen (Desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients [J].

Amagai, M ;

Koch, PJ ;

Nishikawa, T ;

Stanley, JR .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1996, 106 (02) :351-355

[3] IMMUNOPATHOLOGY OF PEMPHIGUS AND BULLOUS PEMPHIGOID [J].

BEUTNER, EH ;

JORDON, RE ;

CHORZELSKI, TP .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1968, 51 (02) :63-+

[4] HISTOLOGY OF LINEAR IGA DISEASE, DERMATITIS-HERPETIFORMIS, AND BULLOUS PEMPHIGOID [J].

BLENKINSOPP, WK ;

HAFFENDEN, GP ;

FRY, L ;

LEONARD, JN .

AMERICAN JOURNAL OF DERMATOPATHOLOGY, 1983, 5 (06) :547-554

[5] CLINICOPATHOLOGICAL CORRELATION IN ERYTHEMA MULTIFORME AND STEVENS-JOHNSON SYNDROME [J].

COTE, B ;

WECHSLER, J ;

BASTUJIGARIN, S ;

ASSIER, H ;

REVUZ, J ;

ROUJEAU, JC .

ARCHIVES OF DERMATOLOGY, 1995, 131 (11) :1268-1272

[6] PEMPHIGOID AND PEMPHIGUS ANTIGENS IN CULTURED EPIDERMAL-CELLS [J].

DIAZ, LA ;

MARCELO, CL .

BRITISH JOURNAL OF DERMATOLOGY, 1978, 98 (06) :631-637

[7] CLONING AND PRIMARY STRUCTURAL-ANALYSIS OF THE BULLOUS PEMPHIGOID AUTOANTIGEN BP180 [J].

GIUDICE, GJ ;

EMERY, DJ ;

DIAZ, LA .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1992, 99 (03) :243-250

[8] The pathophysiology of bullous pemphigoid [J].

Kasperkiewicz, Michael ;

Zillikens, Detlef .

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY, 2007, 33 (1-2) :67-77

[9] A CLINICOPATHOLOGICAL STUDY OF MUCOSAL INVOLVEMENT IN LINEAR IGA DISEASE [J].

KELLY, SE ;

FRITH, PA ;

MILLARD, PR ;

WOJNAROWSKA, F ;

BLACK, MM .

BRITISH JOURNAL OF DERMATOLOGY, 1988, 119 (02) :161-170

[10]

LABIB RS, 1986, J IMMUNOL, V136, P1231

← 1 2 →