Synthesis, crystal structure, DNA-binding and magnetism of copper 15-metallacrown-5 complexes based on glycinehydroxamic acid ligand

被引：17

作者：

Meng, Yanxia ^{[1
]}

Yang, Hua ^{[1
]}

Li, Dacheng ^{[1
]}

Zeng, Suyuan ^{[1
]}

Chen, Guifang ^{[2
]}

Li, Shengli ^{[2
]}

Dou, Jianmin ^{[1
]}

机构：

[1] Liaocheng Univ, Sch Chem & Chem Engn, Shandong Prov Key Lab Chem Energy Storage & Novel, Liaocheng 252059, Peoples R China

[2] Dongchang Coll, Dept Biol & Chem, Liaocheng 252000, Peoples R China

来源：

RSC ADVANCES | 2016年 / 6卷 / 53期

基金：

中国国家自然科学基金;

关键词：

ANTITUMOR-ACTIVITY; CLEAVAGE; CU(II); CYTOTOXICITY; FLUORESCENCE; APOPTOSIS; DY;

D O I：

10.1039/c6ra05239h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Six metallacrown complexes {La(OAc)(H2O)(2)[15-MCCu(N)glyha-5](H2O)(4)}center dot 2NO(3)center dot 5H(2)O (1), {Gd(OAc)(H2O)[15-MCCu(N)glyha-5](H2O)(3)}center dot 2NO(3)center dot 5H(2)O (2), {Tb(OAc)(H2O)[15-MCCu(N)glyha-5](H2O)(4)}center dot 2NO(3)center dot 4H(2)O (3), {Pr(NO3)(H2O)(2)[15-MCCu(N)glyha-5](H2O)}center dot 2NO(3)center dot 8H(2)O (4), {Nd(NO3)(H2O)(2)[15-MCCu(N)glyha-5](H2O)(2)}center dot 2NO(3)center dot 7H(2)O (5) and {Sm(NO3)(H2O)(2)[15-MCCu(N)glyha-5](H2O)(2)}center dot 2NO(3)center dot 6H(2)O (6) (glyha(2-) = dianion glycinehydroxamic acid) have been synthesized and structurally characterized by X-ray single crystal diffraction, IR spectroscopy and elemental analysis. Spectroscopic studies show that these complexes bind to CT-DNA via an intercalative mode and cause a more B-like to a more C-like conformational change. Magnetic measurements indicate that complexes 1, 3, 4, 5 and 6 dominantly show antiferromagnetic interactions between metal centers, whereas complex 2 reveals ferromagnetic interactions.

引用

页码：47196 / 47202

页数：7

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