Effect of peritoneal dialysis fluids on activity of echinocandins against Candida spp. biofilm

被引：4

作者：

Tobudic, Selma ^{[1
]}

Harrison, Nicole ^{[1
]}

Forstner, Christina ^{[1
,2
]}

Kussman, Manuel ^{[1
]}

Burgmann, Heinz ^{[1
]}

机构：

[1] Med Univ Vienna, Div Infect Dis & Trop Med, Dept Internal Med 1, Wahringer Guertel 18-20, A-1090 Vienna, Austria

[2] Jena Univ Hosp, Ctr Infect Dis & Infect Control, Erlanger Allee 101, D-07749 Jena, Germany

来源：

MEDICAL MYCOLOGY | 2017年 / 55卷 / 07期

关键词：

Candida spp; biofilm; echinocandins; peritoneal dialysis; FUNGAL PERITONITIS; ANTIFUNGAL SUSCEPTIBILITY; INFECTIONS RECOMMENDATIONS; ALBICANS BIOFILMS; CASPOFUNGIN; UPDATE; EPISODES; THERAPY; PERIOD;

D O I：

10.1093/mmy/myw145

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Peritoneal dialysis fluids (PDFs) impair microorganisms' growth, which may compromise effectivity of some antimicrobials. The purpose of this study was to investigate the effect of three different PDFs (lactate/bicarbonate-buffered Physioneal 40 (R) with 2.2% glucose, lactate-buffered Nutrineal PD4 (R) with 1.1% amino acid, and lactate-buffered Extraneal (R) with 7.5% icodextrin) on biofilm formation of four different Candida spp and antibiofilm effectiveness of anidulafungin, caspofungin and micafungin against Candida spp. biofilm in PDFs. All tested PDFs attained inhibitory effect on the biofilm formation but also reduced biofilm effectiveness of echinocandins against biofilm in PDFs was detected.

引用

收藏

页码：790 / 793

页数：4

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