A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica

被引：189
|
作者：
Schlossbauer, Axel [1 ,2 ]
Warncke, Simon [3 ]
Gramlich, Philipp M. E. [1 ,2 ]
Kecht, Johann [1 ,2 ]
Manetto, Antonio [3 ]
Carell, Thomas [1 ,2 ]
Bein, Thomas [1 ,2 ]
机构：
[1] Univ Munich LMU, Dept Chem, D-81377 Munich, Germany
[2] Univ Munich LMU, Ctr NanoSci CeNS, D-81377 Munich, Germany
[3] Baseclick GmbH, D-82327 Tutzing, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 28期
关键词：
click chemistry; colloids; DNA; host-guest systems; nanotechnology; RESPONSIVE CONTROLLED-RELEASE; DRUG-DELIVERY; CLICK CHEMISTRY; NANOPARTICLES; FUNCTIONALIZATION; NANOSPHERE; SUPPORTS; SYSTEM;
D O I：
10.1002/anie.201000827
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Letting off steam: A temperature-controlled valve system permits the targeted release of guest fluorescein molecules from the pores of colloidal mesoporous silica particles. The pore-opening temperature is dependent on the length of double-stranded DNA linkers. Avidin proteins that are joined to the DNA by a biotin modification act as the molecular valve at the exits to the pores. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：4734 / 4737
页数：4
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