A Programmable DNA-Based Molecular Valve for Colloidal Mesoporous Silica

被引：189

作者：

Schlossbauer, Axel ^{[1
,2
]}

Warncke, Simon ^{[3
]}

Gramlich, Philipp M. E. ^{[1
,2
]}

Kecht, Johann ^{[1
,2
]}

Manetto, Antonio ^{[3
]}

Carell, Thomas ^{[1
,2
]}

Bein, Thomas ^{[1
,2
]}

机构：

[1] Univ Munich LMU, Dept Chem, D-81377 Munich, Germany

[2] Univ Munich LMU, Ctr NanoSci CeNS, D-81377 Munich, Germany

[3] Baseclick GmbH, D-82327 Tutzing, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 28期

关键词：

click chemistry; colloids; DNA; host-guest systems; nanotechnology; RESPONSIVE CONTROLLED-RELEASE; DRUG-DELIVERY; CLICK CHEMISTRY; NANOPARTICLES; FUNCTIONALIZATION; NANOSPHERE; SUPPORTS; SYSTEM;

D O I：

10.1002/anie.201000827

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Letting off steam: A temperature-controlled valve system permits the targeted release of guest fluorescein molecules from the pores of colloidal mesoporous silica particles. The pore-opening temperature is dependent on the length of double-stranded DNA linkers. Avidin proteins that are joined to the DNA by a biotin modification act as the molecular valve at the exits to the pores. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4734 / 4737

页数：4

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