Determination of the antimalarial drug piperaquine in small volume pediatric plasma samples by LC-MS/MS

被引：27

作者：

Kjellin, Linda L. ^{[1
,2
]}

Dorsey, Grant ^{[3
]}

Rosenthal, Philip J. ^{[3
]}

Aweeka, Francesca ^{[1
]}

Huang, Liusheng ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Clin Pharm, Drug Res Unit, San Francisco, CA 94143 USA

[2] Uppsala Univ, Dept Pharmaceut Biosci, Div Pharmacokinet & Drug Therapy, S-75105 Uppsala, Sweden

[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

BIOANALYSIS | 2014年 / 6卷 / 23期

关键词：

UNCOMPLICATED MALARIA; LIQUID-CHROMATOGRAPHY; LUMEFANTRINE; IONIZATION; CHILDREN; INFANTS; RISK;

D O I：

10.4155/bio.14.254

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Aim: Determination of piperaquine (PQ) in pediatric plasma requires a method with a small sample volume. Results: We report a sensitive LC-MS/MS method for quantitation of PQ with only 25 mu l human plasma. Using a deuterated internal standard (PQ-d(6)), an analytical PFP column, APCI(+) as the ion source and MRM (535/288 for PQ and 541/294 for the IS) for detection, the method has a linear calibration range of 1.5-250 ng/ml with a runtime of 3.0 min per sample. The method was applied to plasma samples from children. Conclusion: The developed LC-MS/MS method is suitable for pediatric studies with small volume plasma samples collected via capillary tubes. One limitation was the performance of PFP columns varied among different brands.

引用

页码：3081 / 3089

页数：9

共 24 条

[1] Antiretroviral Agents and Prevention of Malaria in HIV-Infected Ugandan Children [J].

Achan, Jane ;

Kakuru, Abel ;

Ikilezi, Gloria ;

Ruel, Theodore ;

Clark, Tamara D. ;

Nsanzabana, Christian ;

Charlebois, Edwin ;

Aweeka, Francesca ;

Dorsey, Grant ;

Rosenthal, Philip J. ;

Havlir, Diane ;

Kamya, Moses R. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (22) :2110-2118

[2]

[Anonymous], 2001, GUID IND BIOAN METH

[3]

[Anonymous], 2011, Science Medicines Health, Guideline on bioanalytical method validation.

[4]

[Anonymous], 2010, Guidelines for the treatment of Malaria, DOI DOI 10.1080/03630269.2023.2168201

[5]

[Anonymous], COCHRANE DATABASE SY

[6] Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria [J].

Ashley, Elizabeth A. ;

Stepniewska, Kasia ;

Lindegardh, Niklas ;

Annerberg, Anna ;

Tarning, Joel ;

McGready, Rose ;

Phaiphun, Lucy ;

Singhasivanon, Pratap ;

White, Nicholas J. ;

Nosten, Francois .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2010, 66 (07) :705-712

[7] Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial [J].

Bigira, Victor ;

Kapisi, James ;

Clark, Tamara D. ;

Kinara, Stephen ;

Mwangwa, Florence ;

Muhindo, Mary K. ;

Osterbauer, Beth ;

Aweeka, Francesca T. ;

Huang, Liusheng ;

Achan, Jane ;

Havlir, Diane V. ;

Rosenthal, Philip J. ;

Kamya, Moses R. ;

Dorsey, Grant .

PLOS MEDICINE, 2014, 11 (08)

[8]

Clinical Pharmacology Quality Assurance (CPQA) Program, 2012, CPQA GUID CHROM METH

[9] Short Report: Increased Risk of Early Vomiting among Infants and Young Children Treated with Dihydroartemisinin-Piperaquine Compared with Artemether-Lumefantrine for Uncomplicated Malaria [J].

Creek, Darren ;

Bigira, Victor ;

Arinaitwe, Emmanuel ;

Wanzira, Humphrey ;

Kakuru, Abel ;

Tappero, Jordan ;

Kamya, Moses R. ;

Dorsey, Grant ;

Sandison, Taylor G. .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2010, 83 (04) :873-875

[10] Pharmacokinetic Predictors for Recurrent Malaria After Dihydroartemisinin-Piperaquine Treatment of Uncomplicated Malaria in Ugandan Infants [J].

Creek, Darren J. ;

Bigira, Victor ;

McCormack, Shelley ;

Arinaitwe, Emmanuel ;

Wanzira, Humphrey ;

Kakuru, Abel ;

Tappero, Jordan W. ;

Sandison, Taylor G. ;

Lindegardh, Niklas ;

Nosten, Francois ;

Aweeka, Francesca T. ;

Parikh, Sunil .

JOURNAL OF INFECTIOUS DISEASES, 2013, 207 (11) :1646-1654

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