Real-world evidence on clinical outcomes of people with type 1 diabetes using open-source and commercial automated insulin dosing systems: A systematic review

被引:46
作者
Knoll, Christine [1 ,2 ,3 ]
Peacock, Sofia [4 ,5 ]
Waldchen, Mandy [3 ]
Cooper, Drew [1 ,2 ]
Aulakh, Simran Kaur [6 ]
Raile, Klemens [1 ]
Hussain, Sufyan [4 ,5 ,7 ]
Braune, Katarina [1 ,2 ,8 ]
机构
[1] Charite Univ Med Berlin, Dept Paediat Endocrinol & Diabet, Augustenburger Pl 1, D-13353 Berlin, Germany
[2] Berlin Inst Hlth BIH, Berlin, Germany
[3] Univ Coll Dublin, Sch Sociol, Belfield, Ireland
[4] Guys & St Thomas NHS Fdn Trust, Dept Diabet & Endocrinol, London, England
[5] Kings Coll London, Fac Life Sci & Med, Dept Diabet, London, England
[6] Francis Crick Inst, Mol Biol Metab Lab, London, England
[7] Kings Hlth Partners, Inst Diabet Endocrinol & Obes, London, England
[8] Charite Univ Med Berlin, Inst Med Informat, Berlin, Germany
基金
英国惠康基金;
关键词
automated insulin delivery; automated insulin dosing; diabetes mellitus; diabetes technology; open-source; real-world evidence; type; 1; diabetes; GLUCOSE MONITORING USE; GLYCEMIC CONTROL; HYPOGLYCEMIA; INDIVIDUALS; TRIAL;
D O I
10.1111/dme.14741
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims Several commercial and open-source automated insulin dosing (AID) systems have recently been developed and are now used by an increasing number of people with diabetes (PwD). This systematic review explored the current status of real-world evidence on the latest available AID systems in helping to understand their safety and effectiveness. Methods A systematic review of real-world studies on the effect of commercial and open-source AID system use on clinical outcomes was conducted employing a devised protocol (PROSPERO ID 257354). Results Of 441 initially identified studies, 21 published 2018-2021 were included: 12 for Medtronic 670G; one for Tandem Control-IQ; one for Diabeloop DBLG1; two for AndroidAPS; one for OpenAPS; one for Loop; three comparing various types of AID systems. These studies found that several types of AID systems improve Time-in-Range and haemoglobin A(1c) (HbA(1c)) with minimal concerns around severe hypoglycaemia. These improvements were observed in open-source and commercially developed AID systems alike. Conclusions Commercially developed and open-source AID systems represent effective and safe treatment options for PwD of several age groups and genders. Alongside evidence from randomized clinical trials, real-world studies on AID systems and their effects on glycaemic outcomes are a helpful method for evaluating their safety and effectiveness.
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页数:16
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