Harmine combined with paclitaxel inhibits tumor proliferation and induces apoptosis through down-regulation of cyclooxygenase-2 expression in gastric cancer

被引：18
作者：
Yu, Xiao-Juan [1 ]
Sun, Kun [2 ]
Tang, Xiao-He [2 ]
Zhou, Cun-Jin [2 ]
Sun, Hui [2 ]
Yan, Zhe [2 ]
Fang, Ling [2 ]
Wu, Hong-Wen [2 ]
Xie, Yi-Kui [2 ]
Gu, Bin [1 ]
机构：
[1] Peoples Hosp Taizhou, Dept Emergency, 399 Hailing Rd, Taizhou 225300, Jiangsu, Peoples R China
[2] First Hosp Zibo, Dept Gastroenterol, 4 Emeishan East Rd, Zibo 255200, Shandong, Peoples R China
来源：
ONCOLOGY LETTERS | 2016年 / 12卷 / 02期
关键词：
harmine; paclitaxel; cyclooxygenase-2; gastric cancer; apoptosis; CELL APOPTOSIS; CHEMOTHERAPY; GROWTH; ANGIOGENESIS; CARCINOMA; SURVIVAL;
D O I：
10.3892/ol.2016.4696
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cyclooxygenase-2 (COX-2) serves an important role in the carcinogenesis and progression of gastric cancer. Harmine (UM) and paclitaxel (PTX) are reported as promising drug candidates for cancer therapy, but whether a synergistic anti-tumor effect of HM combined with PTX exists in human gastric cancer remains unknown. The present study evaluated the effects of HM and/or PTX on cell proliferation and apoptosis in a gastric cancer cell line, SGC-7901. HM and PI X inhibited cell proliferation in a dose-dependent manner. Both FIM and PTX alone induced apoptosis in gastric cancer cells. The combination of HM and PI X exerted synergistic effects on proliferation inhibition and apoptosis induction in SGC-7901 cells, with down-regulation of COX-2, PCNA and BcI-2 and up-regulation of Bax expression. The results indicated that combination chemotherapy using HM with PI X exerts an anti-tumor effect for treating gastric cancer. The combination of the two drugs inhibits gastric cancer development more effectively than each drug alone through down-regulation of COX-2 expression.
引用
收藏
页码：983 / 988
页数：6
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