N-Terminal B-type Natriuretic Peptide in Heart Failure

被引：60

作者：

Richards, Arthur Mark ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Natl Univ Heart Ctr, Cardiovasc Res Inst, Cardiol, 1E Kent Ridge Rd,NUHS Tower Block 9th Floor, Singapore 129788, Singapore

[2] Univ Otago, Christchurch Heart Inst, Riccarton Ave, Christchurch 8014, New Zealand

来源：

HEART FAILURE CLINICS | 2018年 / 14卷 / 01期

关键词：

NT-proBNP; Heart failure; Diagnosis; Prognosis; Monitoring; PRESERVED EJECTION FRACTION; BODY-MASS INDEX; DIAGNOSTIC PERFORMANCE; EMERGENCY DIAGNOSIS; ATRIAL-FIBRILLATION; DYSPNEIC PATIENTS; PROGNOSTIC VALUE; BASE-LINE; PROBNP; BNP;

D O I：

10.1016/j.hfc.2017.08.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma amino-terminal pro-B-type natriuretic peptide (NT-proBNP) is a guideline-mandated biomarker in heart failure (HF). Used as an inclusion criterion for therapeutic trials, NT-proBNP enriches trial populations and is a valid surrogate endpoint. Its diagnostic performance is best validated in acute decompensated HF (ADHF). NT-proBNP offers prognostic information independent of standard clinical predictors and refines risk stratification. With the advent of combined angiotensin 2 type 1 receptor blockade and neprilysin inhibition (ARNI), NT-proBNP retains its relationship to cardiac status and is the marker of choice in assessment of possible ADHF and in serial monitoring of HF patients receiving ARNI treatment.

引用

页码：27 / +

页数：14

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