The normobaric oxygen paradox: A novel way to administer oxygen as an adjuvant treatment for cancer?

被引：34

作者：

De Bels, D. ^{[1
,3
]}

Corazza, F. ^{[2
]}

Germonpre, P. ^{[3
,4
]}

Balestra, C. ^{[3
]}

机构：

[1] Brugmann Univ Hosp, Intens Care Unit, Dept Intens Care, B-1030 Brussels, Belgium

[2] Brugmann Univ Hosp, Immunol Lab, B-1030 Brussels, Belgium

[3] Haute Ecole Paul Henri Spaak, Environm & Occupat Physiol Lab, Brussels, Belgium

[4] Queen Astrid Mil Hosp, Hyperbar Ctr, Brussels, Belgium

来源：

MEDICAL HYPOTHESES | 2011年 / 76卷 / 04期

关键词：

CHEMOTHERAPY; ANEMIA; GLUTATHIONE; MANAGEMENT; CELLS; EPO;

D O I：

10.1016/j.mehy.2010.11.022

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The "normobaric oxygen paradox" is a dual mechanism by which oxygen regulates the expression of the Hypoxia Inducible Factor 1 alpha (HIF-1 alpha). The HIF-1 alpha-depending gene regulation is responsible for many different genetic expressions including EPO and VEGF that are usually expressed in parallel. First, VEGF under-expression could decrease tumor angiogenesis leading to a decrease in tumor growth or even apoptosis of cancer cells. Second, induction of EPO-expression can provide cytoprotection. Altogether, this could be deleterious for cancer cells while helping non-malignant cells (at least neural and cardiac) cells to be protected from the side effects of chemotherapy. Eventually, HIF induction could boost immune response by inflammatory cells, increasing their antitumor activity. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：467 / 470

页数：4

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