Chlorinated metabolites with antibacterial activities from a deep-sea-derived Spiromastix fungus

被引：17

作者：

Niu, Siwen ^{[1
,2
]}

Liu, Dong ^{[1
]}

Shao, Zongze ^{[2
]}

Huang, Jiang ^{[1
]}

Fan, Aili ^{[1
]}

Lin, Wenhan ^{[1
,3
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] SOA, Inst Oceanog 3, Xiamen 361005, Peoples R China

[3] Peking Univ, Inst Ocean Res, Ningbo Inst Marine Med, Beijing 100191, Peoples R China

来源：

RSC ADVANCES | 2021年 / 11卷 / 47期

基金：

中国国家自然科学基金;

关键词：

RESORCYLIC ACID LACTONES; MARINE SPONGE; ASCIDIAN SYNOICUM; A-E; DERIVATIVES; INHIBITORS; ALKALOIDS;

D O I：

10.1039/d1ra05736g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chromatographic separation of the solid cultures of a deep-sea-derived Spiromastix fungus (MCCC 3A00308) resulted in the isolation of eight compounds. Their structures were identified on the basis of the spectroscopic data. Compounds 1-8 are classified as depsidone-type (1-4), isocoumarin-type (5 and 6), and benzothiazole-type (7 and 8), of which 1-7 are new compounds and 1-3 along with 5 and 6 are chlorinated. Compound 3 is characterized by trichlorination and shows potent activities against Gram-positive pathogenic bacteria including Staphylococcus aureus ATCC 25923, Bacillus thuringiensis ATCC 10792, and Bacillus subtilis CMCC 63501, with minimum inhibitory concentration (MIC) values ranging from 0.5 to 1.0 mu g mL(-1). This study extends the chemical diversity of chlorinated natural products from marine-derived fungi and provides a promising lead for the development of antibacterial agents.

引用

页码：29661 / 29667

页数：7

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