Persistent reflux symptoms cause anxiety, depression, and mental health and sleep disorders in gastroesophageal reflux disease patients

被引：28

作者：

Kimura, Yoshihide ^{[1
]}

Kamiya, Takeshi ^{[2
]}

Senoo, Kyouji ^{[1
]}

Tsuchida, Kenji ^{[1
]}

Hirano, Atsuyuki ^{[1
]}

Kojima, Hisayo ^{[1
]}

Yamashita, Hiroaki ^{[1
]}

Yamakawa, Yoshihiro ^{[1
]}

Nishigaki, Nobuhiro ^{[1
]}

Ozeki, Tomonori ^{[1
]}

Endo, Masatsugu ^{[1
]}

Nakanishi, Kazuhisa ^{[1
]}

Sando, Motoki ^{[1
]}

Inagaki, Yusuke ^{[3
]}

Shikano, Michiko ^{[3
]}

Mizoshita, Tsutomu ^{[3
]}

Kubota, Eiji ^{[3
]}

Tanida, Satoshi ^{[3
]}

Kataoka, Hiromi ^{[3
]}

Katsumi, Kohei ^{[1
]}

Joh, Takashi ^{[3
]}

机构：

[1] Nagoya City West Med Ctr, Dept Gastroenterol, Kita Ku, 1-1-1 Hirate Cho, Nagoya, Aichi 4628508, Japan

[2] Nagoya City Univ, Grad Sch Med Sci, Dept Med Innovat, Mizuho Ku, 1 Mizuho Cho, Nagoya, Aichi 4678601, Japan

[3] Nagoya City Univ, Grad Sch Med Sci, Dept Gastroenterol & Metab, Mizuho Ku, 1 Mizuho Cho, Nagoya, Aichi 4678601, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2016年 / 59卷 / 01期

关键词：

gastroesophageal reflux disease; health-related quality of life; 8-item Short Form Health Survey; Pittsburgh Sleep Quality Index; Hospital Anxiety and Depression Scale; PROTON PUMP INHIBITORS; QUALITY-OF-LIFE; CLINICAL CHARACTERISTICS; PRIMARY-CARE; THERAPY; ESOMEPRAZOLE; EPIDEMIOLOGY; ESOPHAGITIS; ASSOCIATION; DYSFUNCTION;

D O I：

10.3164/jcbn.16-9

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Some patients with gastroesophageal reflux disease experience persistent reflux symptoms despite proton pump inhibitor therapy. These symptoms reduce their health-related quality of life. Our aims were to evaluate the relationship between proton pump inhibitor efficacy and health-related quality of life and to evaluate predictive factors affecting treatment response in Japanese patients. Using the gastroesophageal reflux disease questionnaire, 145 gastroesophageal reflux disease patients undergoing proton pump inhibitor therapy were evaluated and classified as responders or partial-responders. Their health-related quality of life was then evaluated using the 8-item Short Form Health Survey, the Pittsburgh Sleep Quality Index, and the Hospital Anxiety and Depression Scale questionnaires. Sixty-nine patients (47.6%) were partial responders. These patients had significantly lower scores than responders in 5/8 subscales and in the mental health component summary of the 8-item Short Form Health Survey. Partial responders had significantly higher Pittsburgh Sleep Quality Index and Hospital Anxiety and Depression Scale scores, including anxiety and depression scores, than those of responders. Non erosive reflux disease and double proton pump inhibitor doses were predictive factors of partial responders. Persistent reflux symptoms, despite proton pump inhibitor therapy, caused mental health disorders, sleep disorders, and psychological distress in Japanese gastroesophageal reflux disease patients.

引用

页码：71 / 77

页数：7

共 28 条

[1] Systematic review: the association between symptomatic response to proton pump inhibitors and health-related quality of life in patients with gastro-oesophageal reflux disease [J].