Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria

被引：40

作者：

Frei, Angelo ^{[1
]}

Amado, Maite ^{[1
]}

Cooper, Matthew A. ^{[1
]}

Blaskovich, Mark A. T. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2020年 / 26卷 / 13期

基金：

瑞士国家科学基金会; 英国惠康基金;

关键词：

antibiotics; drug design; metal-based drugs; rhenium; RESISTANT STAPHYLOCOCCUS-AUREUS; PHOTODYNAMIC INACTIVATION; ORGANOMETALLIC COMPOUNDS; ANTIMICROBIAL PROPERTIES; PHOTOPHYSICAL PROPERTIES; CELLS; RUTHENIUM(II); 1,10-PHENANTHROLINE; PHOTOSENSITIZERS; INSERTION;

D O I：

10.1002/chem.201904689

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug-resistant S. aureus and E. coli. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.

引用

页码：2852 / 2858

页数：7

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