Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria

被引:36
作者
Frei, Angelo [1 ]
Amado, Maite [1 ]
Cooper, Matthew A. [1 ]
Blaskovich, Mark A. T. [1 ]
机构
[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia
基金
瑞士国家科学基金会; 英国惠康基金;
关键词
antibiotics; drug design; metal-based drugs; rhenium; RESISTANT STAPHYLOCOCCUS-AUREUS; PHOTODYNAMIC INACTIVATION; ORGANOMETALLIC COMPOUNDS; ANTIMICROBIAL PROPERTIES; PHOTOPHYSICAL PROPERTIES; CELLS; RUTHENIUM(II); 1,10-PHENANTHROLINE; PHOTOSENSITIZERS; INSERTION;
D O I
10.1002/chem.201904689
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug-resistant S. aureus and E. coli. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.
引用
收藏
页码:2852 / 2858
页数:7
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