Resting-state EEG gamma activity in children with Attention-Deficit/Hyperactivity Disorder

被引:69
作者
Barry, Robert J. [1 ,2 ]
Clarke, Adam R. [1 ,2 ]
Hajos, Mihaly [3 ]
McCarthy, Rory [4 ]
Selikowitz, Mark [4 ]
Dupuy, Franca E. [1 ,2 ]
机构
[1] Univ Wollongong, Brain & Behav Res Inst, Wollongong, NSW 2522, Australia
[2] Univ Wollongong, Sch Psychol, Wollongong, NSW 2522, Australia
[3] Pfizer Global Res & Dev, Dept Neurosci, Groton, CT 06340 USA
[4] Sydney Dev Clin, Sydney, NSW 2000, Australia
关键词
Attention-Deficit/Hyperactivity Disorder; Children; EEG; Gamma; DEFICIT-HYPERACTIVITY DISORDER; STIMULANT MEDICATIONS; OSCILLATIONS; SUBTYPES;
D O I
10.1016/j.clinph.2010.04.022
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: Children with Attention-Deficit/Hyperactivity Disorder (AD/HD) have well-described abnormalities in the four traditional EEG bands. However, to date the gamma band has not been widely investigated. This study investigated resting-state EEG in children with AD/HD and matched controls, with a particular focus on gamma activity. Method: Forty children with AD/HD, and 40 age-and sex-matched controls, participated. EEG was recorded from 19 sites during an eyes-closed resting condition and Fourier transformed to provide estimates for absolute and relative power in the delta, theta, alpha, beta and gamma bands. Results: Children with AD/HD had elevated levels of absolute delta and theta power, and decreased levels of absolute beta and gamma power, compared to controls. With relative power measures, children with AD/HD showed enhanced delta and theta activity, with reduced alpha, beta and gamma activity. Inattention scores on the Conners' Parent Rating Scale were negatively correlated with absolute gamma. Conclusions: These patients demonstrate the typical EEG profile in the eyes-closed resting state, over the delta, theta, alpha and beta bands, associated with AD/HD. In addition, compared with controls, they demonstrate reduced absolute and relative gamma activity. These differences appear to contribute importantly to their dysfunctional stimulus processing, and impact their behavioural outcomes. Significance: This resting-state study extends the well-established fast-wave EEG deficits in children with AD/HD to the gamma band, and links that to increased inattention, which is of special importance in understanding their cognitive-processing problems. (C) 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:1871 / 1877
页数:7
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