Strategies for durable β cell replacement in type 1 diabetes

被引：87

作者：

Brusko, Todd M. ^{[1
,2
,3
]}

Russ, Holger A. ^{[4
]}

Stabler, Cherie L. ^{[5
]}

机构：

[1] Univ Florida, Coll Med, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA

[2] Univ Florida, Coll Med, Dept Pediat, Gainesville, FL 32610 USA

[3] Univ Florida, Diabet Inst, Gainesville, FL 32610 USA

[4] Univ Colorado, Barbara Davis Ctr Diabet, Sch Med, Anschutz Med Campus, Aurora, CO 80045 USA

[5] Univ Florida, Coll Engn, Dept Biomed Engn, Gainesville, FL 32610 USA

来源：

SCIENCE | 2021年 / 373卷 / 6554期

关键词：

REGULATORY T-CELLS; IN-VITRO; PANCREATIC PROGENITORS; TRANSPLANTATION; GENERATION;

D O I：

10.1126/science.abh1657

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Technological advancements in blood glucose monitoring and therapeutic insulin administration have improved the quality of life for people with type 1 diabetes. However, these efforts fall short of replicating the exquisite metabolic control provided by native islets. We examine the integrated advancements in islet cell replacement and immunomodulatory therapies that are coalescing to enable the restoration of endogenous glucose regulation. We highlight advances in stem cell biology and graft site design, which offer innovative sources of cellular material and improved engraftment. We also cover cutting-edge approaches for preventing allograft rejection and recurrent autoimmunity. These insights reflect a growing understanding of type 1 diabetes etiology, beta cell biology, and biomaterial design, together highlighting therapeutic opportunities to durably replace the beta cells destroyed in type 1 diabetes.

引用

页码：516 / 521

页数：6

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