Drug-resistant malaria - an insight

被引：165
作者：
Hyde, John E. [1 ]
机构：
[1] Univ Manchester, Fac Life Sci, Manchester Interdisciplinary Bioctr, Manchester M1 7DN, Lancs, England
来源：
FEBS JOURNAL | 2007年 / 274卷 / 18期
基金：
英国惠康基金;
关键词：
antifolates; artemisinins; atovaquone; chloroquine; combination therapy; gene copy number; gene polymorphisms; Plasmodium falciparum; FALCIPARUM CYTOCHROME-B; PLASMODIUM-FALCIPARUM; CHLOROQUINE RESISTANCE; DIHYDROFOLATE-REDUCTASE; ARTEMETHER-LUMEFANTRINE; ANTIFOLATE RESISTANCE; PLASMODIUM-FALCIPARUM-PFMDR1; ALLELES; SULFADOXINE-PYRIMETHAMINE; ATOVAQUONE RESISTANCE; QUININE RESISTANCE;
D O I：
10.1111/j.1742-4658.2007.05999.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Despite intensive research extending back to the 1930s, when the first synthetic antimalarial drugs made their appearance, the repertoire of clinically licensed formulations remains very limited. Moreover, widespread and increasing resistance to these drugs contributes enormously to the difficulties in controlling malaria, posing considerable intellectual, technical and humanitarian challenges. A detailed understanding of the molecular mechanisms underlying resistance to these agents is emerging that should permit new drugs to be rationally developed and older ones to be engineered to regain their efficacy. This review summarizes recent progress in analysing the causes of resistance to the major antimalarial drugs and its spread.
引用
收藏
页码：4688 / 4698
页数：11
相关论文
共 80 条
  • [1] Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (Encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10
    Afonso, A
    Hunt, P
    Cheesman, S
    Alves, AC
    Cunha, CV
    do Rosário, V
    Cravo, P
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (02) : 480 - 489
  • [2] Increasing prevalence of wildtypes in the dihydrofolate reductase gene of Plasmodium falciparum in an area with high levels of sulfadoxine/pyrimethamine resistance after introduction of treated bed nets
    Alifrangis, M
    Lemnge, MM
    Ronn, AM
    Segeja, MD
    Magesa, SM
    Khalil, IF
    Bygbjerg, IC
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2003, 69 (03) : 238 - 243
  • [3] PFMDR1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border
    Alker, Alisa P.
    Lim, Pharath
    Sem, Rithy
    Shah, Naman K.
    Yi, Poravuth
    Bouth, Denis Mey
    Tsuyuoka, Reiko
    Maguire, Jason D.
    Fandeur, Thierry
    Ariey, Frederic
    Wongsrichanalai, Chansuda
    Meshnick, Steven R.
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2007, 76 (04) : 641 - 647
  • [4] Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?
    Anderson, TJC
    Nair, S
    Qin, H
    Singlam, S
    Brockman, A
    Paiphun, L
    Nosten, F
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (06) : 2180 - 2188
  • [5] The origins and spread of antimalarial drug resistance: Lessons for policy makers
    Anderson, TJC
    Roper, C
    [J]. ACTA TROPICA, 2005, 94 (03) : 269 - 280
  • [6] Molecular mechanisms of resistance in antimalarial chemotherapy: The unmet challenge
    Arav-Boger, R
    Shapiro, TA
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2005, 45 : 565 - +
  • [7] Invasion of Africa by a single pfcrt allele of South East Asian type
    Ariey, Frederic
    Fandeur, Thierry
    Durand, Remy
    Randrianarivelojosia, Milijaona
    Jambou, Ronan
    Legrand, Eric
    Ekala, Marie Therese
    Bouchier, Christiane
    Cojean, Sandrine
    Duchemin, Jean Bernard
    Robert, Vincent
    Le Bras, Jacques
    Mercereau-Puijalon, Odile
    [J]. MALARIA JOURNAL, 2006, 5 (1)
  • [8] Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance
    Berry, A.
    Senescau, A.
    Lelievre, J.
    Benoit-Vical, F.
    Fabre, R.
    Marchou, B.
    Magnaval, J. F.
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2006, 100 (10) : 986 - 988
  • [9] PfCRT and the trans-vacuolar proton electrochemical gradient:: regulating the access of chloroquine to ferriprotoporphyrin IX
    Bray, Patrick G.
    Mungthin, Mathirut
    Hastings, Ian M.
    Biagini, Giancarlo A.
    Saidu, Dauda K.
    Lakshmanan, Viswanathan
    Johnson, David J.
    Hughes, Ruth H.
    Stocks, Paul A.
    O'Neill, Paul M.
    Fidock, David A.
    Warhurst, David C.
    Ward, Stephen A.
    [J]. MOLECULAR MICROBIOLOGY, 2006, 62 (01) : 238 - 251
  • [10] Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance
    Bray, PG
    Martin, RE
    Tilley, L
    Ward, SA
    Kirk, K
    Fidock, DA
    [J]. MOLECULAR MICROBIOLOGY, 2005, 56 (02) : 323 - 333
12345678