Evidence for two independent functional variants for androgenetic alopecia around the androgen receptor gene

被引：24

作者：

Cobb, Joanna E. ^{[2
]}

Zaloumis, Sophie G. ^{[2
]}

Scurrah, Katrina J. ^{[3
]}

Harrap, Stephen B. ^{[2
]}

Ellis, Justine A. ^{[1
,2
]}

机构：

[1] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Dept Physiol, Melbourne, Vic, Australia

[3] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia

来源：

EXPERIMENTAL DERMATOLOGY | 2010年 / 19卷 / 11期

关键词：

androgen receptor; ectodysplasin A2 receptor; male pattern baldness; non-coding DNA; MALE-PATTERN BALDNESS; SUSCEPTIBILITY; POLYMORPHISM; ASSOCIATION; 20P11; RISK;

D O I：

10.1111/j.1600-0625.2010.01132.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The gene encoding the androgen receptor (AR) is associated with male pattern baldness (androgenetic alopecia - AGA). In case-control and family analyses, we mapped AR and the adjacent intergenic regions. We found evidence for association with two independent loci, one upstream and previously described and the other downstream and apparently novel. The haplotype comprising these SNPs was strongly associated with AGA (P = 3.75 x 10-5) in 1195 men. We also replicated association with a recently reported non-coding region on chromosome 20 and found that its association with AGA was less strong and independent of that of AR. Our results will help focus future efforts to further define AGA genetic risk.

引用

页码：1026 / 1028

页数：3

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