ABCB1 and ABCG2 expression in the placenta and fetus: an interspecies comparison

被引：18
作者：
Myllynen, Paivi [1 ]
Kummu, Maria [1 ,2 ]
Sieppi, Elina [1 ]
机构：
[1] Univ Oulu, Inst Biomed, Dept Pharmacol & Toxicol, FIN-90014 Oulu, Finland
[2] Univ Oulu, Ctr Arctic Med, Thule Inst, FIN-90014 Oulu, Finland
来源：
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2010年 / 6卷 / 11期
关键词：
CANCER RESISTANCE PROTEIN; P-GLYCOPROTEIN EXPRESSION; LIMITS FETAL DISTRIBUTION; MULTIDRUG-RESISTANCE; PHOSPHOGLYCOPROTEIN ABCB1; DRUG TRANSPORTERS; GENE-EXPRESSION; MOUSE PLACENTA; RAT PLACENTA; BCRP/ABCG2;
D O I：
10.1517/17425255.2010.514264
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Areas covered in this review: Comprehensive literature searches were done using PubMed (until June 2010) to identify publications on ABCB1 and ABCG2 expression in placenta and fetal tissues in human, mouse, rat, guinea-pig and rabbit. What the reader will gain: In this review, we aim to provide an overview of the current knowledge on the ABCB1 and ABCG2 transporter expression profiles in the placenta and fetal tissues in humans relative to other species. Take home message: The available information on ABCB1 and ABCG2 temporal expression profiles in placenta and fetus indicates rather good correlation among human, mouse and rat although some specific differences have been reported. However, at this point no detailed comparisons or comparative functional data are available. Detailed knowledge on the expression patterns and functional activity of ABCB1 and ABCG2 transporters placenta and developing embryo/fetus in different species could possibly help the interspecies extrapolation.
引用
收藏
页码：1385 / 1398
页数：14
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