Toward Carbon-Nanotube-Based Theranostic Agents for Microwave Detection and Treatment of Breast Cancer: Enhanced Dielectric and Heating Response of Tissue-Mimicking Materials

被引:102
作者
Mashal, Alireza [1 ]
Sitharaman, Balaji [2 ]
Li, Xu [3 ]
Avti, Pramod K. [2 ]
Sahakian, Alan V. [3 ]
Booske, John H. [1 ]
Hagness, Susan C. [1 ]
机构
[1] Univ Wisconsin, Dept Elect & Comp Engn, Madison, WI 53706 USA
[2] SUNY Stony Brook, Dept Biomed Engn, Stony Brook, NY 11794 USA
[3] Northwestern Univ, Dept Biomed Engn, Evanston, IL 60208 USA
基金
美国国家卫生研究院;
关键词
Breast cancer; carbon nanotubes; contrast agent; dielectric spectroscopy; microwave hyperthermia; microwave imaging; phantoms; IN-VIVO; COMPOSITES; MICE; SPECTROSCOPY; FREQUENCIES; PROBES; BAND;
D O I
10.1109/TBME.2010.2042597
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The experimental results reported in this paper suggest that single-walled carbon nanotubes (SWCNTs) have the potential to enhance dielectric contrast between malignant and normal tissue for microwave detection of breast cancer and facilitate selective heating of malignant tissue for microwave hyperthermia treatment of breast cancer. In this study, we constructed tissue-mimicking materials with varying concentrations of SWCNTs and characterized their dielectric properties and heating response. At SWCNT concentrations of less than 0.5% by weight, we observed significant increases in the relative permittivity and effective conductivity. In microwave heating experiments, we observed significantly greater temperature increases in mixtures containing SWCNTs. These temperature increases scaled linearly with the effective conductivity of the mixtures. This work is a first step towards the development of functionalized, tumor-targeting SWCNTs as theranostic (integrated therapeutic and diagnostic) agents for microwave breast cancer detection and treatment.
引用
收藏
页码:1831 / 1834
页数:4
相关论文
共 28 条
[21]  
SHEA JD, INVERSE PRO IN PRESS
[22]   Gadofullerenes and gadonanotubes: A new paradigm for high-performance magnetic resonance imaging contrast agent probes [J].
Sitharaman, Balaji ;
Wilson, Lon J. .
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2007, 3 (04) :342-352
[23]   Theranostic nanomedicine for cancer [J].
Sumer, Baran ;
Gao, Jinming .
NANOMEDICINE, 2008, 3 (02) :137-140
[24]   Focused microwave phased array thermotherapy for ablation of early-stage breast cancer: Results of thermal dose escalation [J].
Vargas, HI ;
Dooley, WC ;
Gardner, RA ;
Gonzalez, KD ;
Venegas, R ;
Heywang-Kobrunner, SH ;
Fenn, AJ .
ANNALS OF SURGICAL ONCOLOGY, 2004, 11 (02) :139-146
[25]   Microwave (8-50 GHz) characterization of multiwalled carbon nanotube papers using rectangular waveguides [J].
Wang, Lu ;
Zhou, Rongguo ;
Xin, Hao .
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, 2008, 56 (02) :499-506
[26]   Microwave attenuation of multiwalled carbon nanotube-fused silica composites [J].
Xiang, CS ;
Pan, YB ;
Liu, XJ ;
Sun, XW ;
Shi, XM ;
Guo, JK .
APPLIED PHYSICS LETTERS, 2005, 87 (12) :1-3
[27]   Breast cancer imaging by microwave-induced thermoacoustic tomography [J].
Xu, MH ;
Ku, G ;
Jin, X ;
Wang, LHV ;
Fornage, BD ;
Hunt, KK .
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2005, 2005, 5697 :45-48
[28]  
ZASTROW E, 2003, PHYS MED BI IN PRESS